36792-49-1Relevant academic research and scientific papers
Structure-activity relationships of uridine 5′-diphosphate analogues at the human P2Y6 receptor
Besada, Pedro,Shin, Dae Hong,Costanzi, Stefano,Ko, Hyojin,Mathé, Christophe,Gagneron, Julien,Gosselin, Gilles,Maddileti, Savitri,Harden, T. Kendall,Jacobson, Kenneth A.
, p. 5532 - 5543 (2007/10/03)
The structure-activity relationships and molecular modeling of the uracil nucleotide activated P2Y6 receptor have been studied. Uridine 5′-diphosphate (UDP) analogues bearing substitutions of the ribose moiety, the uracil ring, and the diphosph
Biological activity and phosphorylation of 2'-azido-2'-deoxyuridine and 2'-azido-2'-deoxycytidine
Kang, Shin Hong,Cho, Moo J.
, p. 1077 - 1088 (2007/10/03)
2'-Azido-2'-deoxyuridine and 2'-azido-2'-deoxycytidine were evaluated for their inhibitory activity against ribonucleotide reductase and for subsequent cell growth inhibition. Their mono- and di-phosphates were synthesized and their inhibitory activities against the reductase were also determined in a permeabilized cell system, along with the two nucleosides. The results of the present study identify the first phosphorylation step involved in the conversion of the two azidonucleosides to the corresponding diphosphates to be rate-limiting in the overall activation.
