36799-17-4 Usage
Uses
Used in Pharmaceutical Industry:
Guanosine, 8-methylis used as a therapeutic agent for its potential applications in treating various diseases. Its role in regulating gene expression and mediating protein synthesis makes it a promising candidate for developing targeted therapies against cancer and viral infections.
Used in Biotechnology Industry:
Guanosine, 8-methylis used as a key component in the development of novel drug delivery systems and gene therapies. Its presence in tRNA molecules and its ability to stabilize their structure make it a valuable tool for enhancing the efficiency and specificity of these therapeutic approaches.
Used in Research and Development:
Guanosine, 8-methylis utilized in research settings to study the molecular mechanisms underlying protein synthesis, gene regulation, and disease pathogenesis. Its unique properties and potential therapeutic applications make it an important molecule for advancing our understanding of biological processes and developing new treatment strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 36799-17-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,7,9 and 9 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 36799-17:
(7*3)+(6*6)+(5*7)+(4*9)+(3*9)+(2*1)+(1*7)=164
164 % 10 = 4
So 36799-17-4 is a valid CAS Registry Number.
36799-17-4Relevant academic research and scientific papers
Zady, Mona F.,Wong, John L.
, p. 2373 - 2377 (1980)
Five nucleosides, adenosine, guanosine, cytidine, thymidine, and uridine, were allowed to react with methyl radical produced by homolysis of tert-butyl peracetate.The extent and sites of reaction exhibited a marked dependence on the pH of the aqueous medium.In the region of pH 1-4, the major products arose from C-methylation of the nucleosides.The purines were more reactive than the pyrimidines under these acidic conditions.In the pH range of 4-10, the extent of C-methylation decreased steadily with increasing pH while N-methylated products arising from methylationof the ring nitrogen and/or exocyclic amino groups predominated.In this pH range, the pyrimidine nucleosides were the more reactive.Beyond pH 10, the extent of methylation diminished in all cases as decomposition of tert-butyl peracetate became rampant.The C-methylation occurs by way of an addition mechanism while N-methylation appears to proceed via radical abstraction of a hydrogen from the N-H group followed by combination with methyl radical.The implications of these reactivity and methylation patterns in radical carcinogenesis are discussed.
