3680-96-4

Basic information

• Product Name: 5-MORPHOLIN-4-YL-FURAN-2-CARBALDEHYDE
• Synonyms: CHEMBRDG-BB 4300152;5-MORPHOLIN-4-YL-FURAN-2-CARBALDEHYDE;5-MORPHOLIN-4-YL-2-FURALDEHYDE;5-morpholinofuran-2-carbaldehyde;5-morpholin-4-yl-2-furaldehyde(SALTDATA: FREE)
• CAS NO: 3680-96-4
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.19
• Mol File: 3680-96-4.mol

Chemical Properties

• Boiling Point: 354.5 °C at 760 mmHg
• Flash Point: 168.2 °C
• Appearance: /
• Density: 1.23 g/cm³
• Vapor Pressure: 3.34E-05mmHg at 25°C
• Refractive Index: 1.553
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-MORPHOLIN-4-YL-FURAN-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-MORPHOLIN-4-YL-FURAN-2-CARBALDEHYDE(3680-96-4)
• EPA Substance Registry System: 5-MORPHOLIN-4-YL-FURAN-2-CARBALDEHYDE(3680-96-4)

Safety Data

• Hazardous Substances Data: 3680-96-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
5-Morpholin-4-yl-furan-2-carbaldehyde is used as a key intermediate in the synthesis of pharmaceuticals for its potential pharmacological activity. Its unique structure allows it to be a building block in the creation of new drug molecules, contributing to the advancement of medicinal chemistry.
Used in Organic Synthesis:
In the field of organic synthesis, 5-Morpholin-4-yl-furan-2-carbaldehyde serves as a valuable precursor for the preparation of a variety of organic compounds. Its reactive aldehyde group and morpholine ring make it a versatile component in the synthesis of complex organic molecules.
Used in Chemical Research:
5-Morpholin-4-yl-furan-2-carbaldehyde is utilized as a subject of study in chemical research to explore its properties, reactivity, and potential applications. This research can lead to a better understanding of its behavior in various chemical reactions and its integration into novel chemical processes.
Used in Drug Discovery:
As a compound with potential pharmacological activity, 5-Morpholin-4-yl-furan-2-carbaldehyde is used in drug discovery processes. It may serve as a lead compound for the development of new therapeutic agents, particularly in the areas of medicine where its specific properties can be harnessed to target particular biological pathways or mechanisms.
Used in Medicinal Chemistry:
In medicinal chemistry, 5-Morpholin-4-yl-furan-2-carbaldehyde is employed as a structural element in the design of new drugs. Its incorporation into drug candidates can potentially enhance their efficacy, selectivity, or pharmacokinetic properties, making it an important component in the development of innovative pharmaceuticals.

InChI:InChI=1/C9H11NO3/c11-7-8-1-2-9(13-8)10-3-5-12-6-4-10/h1-2,7H,3-6H2

Upstream product

• 110-91-8 morpholine 
• 2689-65-8 5-iodofuran-2-carbaldehyde 
• 3680-95-3 [1-(5-Iodo-furan-2-yl)-meth-(E)-ylidene]-phenyl-amine 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 31795-44-5 5-formyl-2-furansulfonic acid sodium salt 
• 5207-56-7 5-N-morpholylfurfurylidene-N-morpholidium iodide 

Downstream Products

• 84966-23-4 (1-Hydroxycyclohexyl)-N-(5-morpholinofurfuryliden)methanamin-N-oxid 
• 1146445-69-3 (2R,3S,9br)-ethyl 2,3,5,9b-tetrahydro-3-methyl-7-morpholino-5-oxo-2-phenyloxazolo[2,3-a]isoindole-6-carboxylate 
• 1146445-65-9 (3S,9bR)-ethyl 3-benzyl-2,3,5,9b-tetrahydro-7-morpholino-5-oxooxazolo[2,3-a]isoindole-6-carboxylate 
• 1146445-63-7 (3R,9bS)-ethyl 2,3,5,9b-tetrahydro-7-morpholino-5-oxo-3-phenyloxazolo[2,3-a]isoindole-6-carboxylate 
• 1225043-38-8 ethyl 2-(4-methoxyphenyl)-5-morpholino-3-oxo-2,3-dihydro-1H-isoindole-4-carboxylate 
• 444668-27-3 C₁₆H₁₈N₂O₂ 
• 1144506-68-2 1-(5-morpholinofur-2-yl)-1-phenylmethanol 
• 1017832-06-2 C₁₉H₁₆N₂O₄ 
• 54478-76-1 4-[5-(4-nitro-phenylazo)-furan-2-yl]-morpholine 

Relevant articles and documents

A facile preparation of trisubstituted amino-furan and -thiophene derivatives

β-Alkylation of amino-furan and -thiophene heterocycles is described through metal-, acid- and base-free carbon-carbon bond formation. The ability of both heterocycles to undergo selective β-alkylation is compared by mean of experimental and theoretical data. The presence of chiral amine substituents induced the diastereoselective generation of the newly formed additional stereocenter.

From furans to anilines: Toward one-pot two-step amination/Diels-Alder sequences

(Chemical Equation Presented) Selective metal-free amination and Diels-Alder reactions are described in the furan series, leading to polysubstituted anilines or to stable oxabicyclic adducts in high yield. Interestingly, anilines are conveniently prepared through a novel one-pot, two-step amination/Diels-Alder procedure from commercially available 5-bromo-2-furaldehyde.

BCRP/ABCG2 INHIBITOR

The present invention is directed to a breast cancer resistance protein (BCRP/ABCG2) inhibitor. The BCRP inhibitor contains, as an active ingredient, an acrylonitrile derivative represented by formula (1): wherein one of R1 and R2 re

Convenient amination of weakly activated thiophenes, furans and selenophenes in aqueous media

We describe herein a new amination procedure of weakly activated heterocyclic bromo derivatives in aqueous media. The base catalysed mechanism of this reaction is also confirmed. Moreover, the application of this strategy to the preparation of amino furans and selenophenes is outlined.

Ring-Chain Isomerism of N-(2-Hydroxyalkyl)nitrones, III. Nitrones of 2-Furancarbaldehydes

The ring-chain isomerism of N-(2-hydroxyalkyl)nitrones 3, obtained from 2-furancarbaldehyde and its 5-dialkylamino and 5-nitro derivatives, is studied by acylation of 3 with diphenylborinic acid, carboxylic acids, and isocyanates.Dependent on the kind of

Mechanism of the Reaction of Aldehydes of the Furan Series with Secondary Amines in Methanol

The reaction of 5-halofurfurals with piperidine and morpholine in methanol under various reaction conditions was investigated by means of spectrophotometry.The kinetics of the stepwise addition of the amine to the aldehyde function of the halofurfural were studied in the case of a dilute solution, while the conversion of the aldehyde to a 5-N,N-dialkylaminofurfurylidene-N,N-dialkylimmonium salt, for which two autocatalysis mechanisms were observed, was investigated in the case of a concentrated solution.Reaction intermediates, viz., 5-halofurfurylidene-N,N-bis(dialkylamines), were isolated preparatively and investigated.