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36820-78-7

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36820-78-7 Usage

Description

3-Formyl-5-methoxy-1H-indole-2-carboxylic acid ethyl ester is a chemical compound with the formula C13H13NO4. It is an ethyl ester derivative of 3-formyl-5-methoxy-1H-indole-2-carboxylic acid, an indole derivative that is widely used in organic synthesis and medicinal chemistry. 3-FORMYL-5-METHOXY-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER is known for its potential pharmacological activities, such as antifungal and antitumor properties, and its versatile structure makes it a valuable building block for the synthesis of various pharmaceuticals and biologically active molecules.

Uses

Used in Pharmaceutical Industry:
3-Formyl-5-methoxy-1H-indole-2-carboxylic acid ethyl ester is used as a key intermediate in the synthesis of pharmaceuticals for its potential antifungal and antitumor activities. Its unique structure allows for the development of new drugs that can target specific biological pathways and diseases.
Used in Organic Synthesis:
In the field of organic synthesis, 3-Formyl-5-methoxy-1H-indole-2-carboxylic acid ethyl ester serves as a versatile building block for the creation of various biologically active molecules. Its reactivity and functional groups enable chemists to modify and incorporate it into complex molecular structures, leading to the discovery of novel compounds with potential therapeutic applications.
Used in Medicinal Chemistry:
3-Formyl-5-methoxy-1H-indole-2-carboxylic acid ethyl ester is utilized in medicinal chemistry as a starting material for the design and synthesis of new drug candidates. Its unique properties and potential pharmacological activities make it an attractive scaffold for the development of innovative therapeutic agents targeting a range of diseases and conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 36820-78-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,8,2 and 0 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 36820-78:
(7*3)+(6*6)+(5*8)+(4*2)+(3*0)+(2*7)+(1*8)=127
127 % 10 = 7
So 36820-78-7 is a valid CAS Registry Number.
InChI:InChI=1/C13H13NO4/c1-3-18-13(16)12-10(7-15)9-6-8(17-2)4-5-11(9)14-12/h4-7,14H,3H2,1-2H3

36820-78-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl 3-formyl-5-methoxy-1H-indole-2-carboxylate

1.2 Other means of identification

Product number -
Other names ethyl 3-formyl-5-methoxy-1H-indole-2-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:36820-78-7 SDS

36820-78-7Relevant articles and documents

COMPOSITIONS AND METHODS FOR ACTIVATING PYRUVATE KINASE

-

Page/Page column 51-52; 68, (2022/02/05)

Provided herein are compositions and methods for activating pyruvate kinase (e.g., in a subject). In particular, provided herein are compositions and methods for treating a disease or condition (e.g., eye disease, blood disorders, or cancer) using pyruvate kinase activators.

Design of C3-Alkenyl-Substituted 2-Indolylmethanols for Catalytic Asymmetric Interrupted Nazarov-Type Cyclization

Wang, Cong-Shuai,Wu, Jia-Le,Li, Can,Li, Lin-Zhi,Mei, Guang-Jian,Shi, Feng

supporting information, p. 846 - 851 (2018/03/06)

The C3-alkenyl-substituted 2-indolylmethanols have been designed as a new class of substrates for catalytic asymmetric interrupted Nazarov-type cyclizations. In the presence of chiral phosphoric acid as a mild chiral Br?nsted acid, the interrupted Nazarov

Synthesis and biological evaluation of indolyl-pyridinyl-propenones having either methuosis or microtubule disruption activity

Trabbic, Christopher J.,Overmeyer, Jean H.,Alexander, Evan M.,Crissman, Emily J.,Kvale, Heather M.,Smith, Marcie A.,Erhardt, Paul W.,Maltese, William A.

, p. 2489 - 2512 (2015/03/30)

Methuosis is a form of nonapoptotic cell death characterized by an accumulation of macropinosome-derived vacuoles with eventual loss of membrane integrity. Small molecules inducing methuosis could offer significant advantages compared to more traditional anticancer drug therapies that typically rely on apoptosis. Herein we further define the effects of chemical substitutions at the 2-and 5-indolyl positions on our lead compound 3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propene-1-one (MOMIPP). We have identified a number of compounds that induce methuosis at similar potencies, including an interesting analogue having a hydroxypropyl substituent at the 2-position. In addition, we have discovered that certain substitutions on the 2-indolyl position redirect the mode of cytotoxicity from methuosis to microtubule disruption. This switch in activity is associated with an increase in potency as large as 2 orders of magnitude. These compounds appear to represent a new class of potent microtubule-active anticancer agents.

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