36827-98-2

Usage

Uses

Used in Pharmaceutical Research and Development:
FPPE is utilized as a key intermediate in the synthesis of pharmaceuticals for the treatment of various diseases and conditions. Its role in medicinal chemistry is pivotal, as it contributes to the development of new drug candidates with potential therapeutic benefits.
Used in Agrochemical Development:
In the agrochemical industry, FPPE is employed as a building block for the synthesis of compounds that can be used in the development of pesticides, herbicides, and other agricultural chemicals, thereby enhancing crop protection and yield.
Used in the Synthesis of Functional Materials:
Beyond its applications in medicine and agriculture, FPPE is also used in the creation of functional materials with specific properties required for various industrial applications, showcasing its versatility in chemical synthesis.

InChI:InChI=1/C12H9FN2O/c13-10-3-1-9(2-4-10)12(16)7-11-5-6-14-8-15-11/h1-6,8H,7H2

Upstream product

• 3438-46-8 4-Methylpyrimidine 
• 451-46-7 4-fluorobenzoic acid ethyl ester 

Downstream Products

• 897644-70-1 5-amino-3-(4-fluorophenyl)-4-(4-pyrimidinyl)isoxazole 

Relevant academic research and scientific papers

An efficient and practical method for the synthesis of the 5-acylamino-4-(4-pyrimidinyl)isoxazole derivative AKP-001, a potent P38 map kinase inhibitor

5-Acylamino-4-(4-pyrimidinyl)isoxazole derivative AKP-001 is a p38 mitogen-activated protein kinase inhibitor previously developed in our laboratory as an anti-inflammatory agent. Herein, we report our studies leading to the development of an improved syn

The application of flow microreactors to the preparation of a family of casein kinase i inhibitors

In this article we demonstrate how a combination of enabling technologies such as flow synthesis, solid-supported reagents and scavenging resins utilised under fully automated software control can assist in typical medicinal chemistry programmes. In particular automated continuous flow methods have greatly assisted in the optimisation of reaction conditions and facilitated scale up operations involving hazardous chemical materials. Overall a collection of twenty diverse analogues of a casein kinase I inhibitor has been synthesised by changing three principle binding vectors.

Pyrazolo[1,5-a]pyridines as p38 kinase inhibitors

(Chemical Equation Presented) A convergent synthesis of substituted pyrazolo[1,5-a]pyridines has been achieved either via a regioselective [3 + 2] cycloaddition of N-aminopyridines with alkynes or by thermal cyclization of disubstituted azirines. Subseque

PYRAZOLOPYRIDINE DERIVATES

New compounds of formula (I) and the salts, solvates and prodrugs thereof, wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as p38 kinase inhibitors.

Fused pyrazole derivatives bieng protein kinase inhibitors

Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R1, (R2, and R4 are various substituent groups, are protein kinase inhibitors.