36841-48-2

Basic information

• Product Name: [2-(4-BROMO-PHENYL)-OXAZOL-4-YL]-METHANOL
• Synonyms: [2-(4-BROMO-PHENYL)-OXAZOL-4-YL]-METHANOL
• CAS NO: 36841-48-2
• Molecular Formula: C₁₀H₈BrNO₂
• Molecular Weight: 254.08
• Mol File: 36841-48-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 388.186 °C at 760 mmHg
• Flash Point: 188.568 °C
• Appearance: /
• Density: 1.581 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.605
• CAS DataBase Reference: [2-(4-BROMO-PHENYL)-OXAZOL-4-YL]-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(4-BROMO-PHENYL)-OXAZOL-4-YL]-METHANOL(36841-48-2)
• EPA Substance Registry System: [2-(4-BROMO-PHENYL)-OXAZOL-4-YL]-METHANOL(36841-48-2)

Safety Data

• Hazardous Substances Data: 36841-48-2(Hazardous Substances Data)

Usage

General Description

[2-(4-Bromo-phenyl)-oxazol-4-yl]-methanol is a chemical compound with a molecular formula of C9H8BrNO2. It is a white to off-white powder that is often used as a building block in the synthesis of various pharmaceuticals and organic compounds. [2-(4-BROMO-PHENYL)-OXAZOL-4-YL]-METHANOL contains a benzene ring with a bromine atom and an oxazole ring, which gives it unique properties and reactivity. It can be used in the synthesis of various biologically active compounds, making it an important intermediate in the pharmaceutical and chemical industries. Additionally, it is important to handle this chemical with caution, as it may pose health and environmental risks if not properly handled and disposed of.

InChI:InChI=1/C10H8BrNO2/c11-8-3-1-7(2-4-8)10-12-9(5-13)6-14-10/h1-4,6,13H,5H2

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 1239589-17-3 methyl 2-(4-bromophenyl)-1,3-oxazole-4-carboxylate 
• 6704-31-0 oxetan-3-one 
• 698-67-9 p-bromobenzamide 
• 22091-38-9 2-(4-bromophenyl)-4-(chloromethyl)oxazole 

Downstream Products

• 36841-59-5 [5-bromo-2-(4-bromo-phenyl)-oxazol-4-yl]-methanol 
• 22091-38-9 2-(4-bromophenyl)-4-(chloromethyl)oxazole 

Relevant articles and documents

Discovery of the disubstituted oxazole analogues as a novel class anti-tuberculotic agents against MDR- and XDR-MTB

A high-throughput screening effort on 45,000 compounds resulted in the discovery of a disubstituted oxazole as a new structural class inhibitor of Mycobacterium tuberculosis (Mtb). In order to improve the activity and investigate the SAR of this scaffold, a series of disubstituted azole analogues have been designed and synthesized. The newly synthesized compounds 1a-y were evaluated for their in vitro anti-TB activity versus replicating, multi- and extensive drug resistant Mtb strains. All the compounds, except 1o, 1p and 1q, showed potent anti-TB activity with MIC of 1-64 mg/L. The test of broad spectrum panel revealed that this series are specific to Mtb. The cytotoxicity assessment indicated that the compounds were not cytotoxic against HEK 293 cells. The compounds could have a novel mechanism to anti-Mtb as they can inhibit drug sensitive and drug resistant Mtb.

Nitration and halogenation of various 2-aryl-4-chloro-methyl-oxazoles. 23. Heterocyclic compounds

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