368426-90-8

Basic information

• Product Name: Carbamic acid, [(3-amino-1H-indazol-5-yl)methyl]-, 1,1-dimethylethyl ester
• CAS NO: 368426-90-8
• Molecular Formula: C13H18N4O2
• Molecular Weight: 262.312
• Mol File: 368426-90-8.mol

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(3-amino-1H-indazol-5-yl)methyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(3-amino-1H-indazol-5-yl)methyl]-, 1,1-dimethylethyl ester(368426-90-8)
• EPA Substance Registry System: Carbamic acid, [(3-amino-1H-indazol-5-yl)methyl]-, 1,1-dimethylethyl ester(368426-90-8)

Safety Data

• Hazardous Substances Data: 368426-90-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Indibulin is used as an antineoplastic agent for its potential use in the treatment of various types of cancer, including breast, prostate, and non-small cell lung cancer. It disrupts microtubule dynamics, leading to cell cycle arrest and apoptosis in cancer cells, making it a promising candidate for further research and development as a potential anti-cancer drug.

Upstream product

• 368426-85-1 5-(azidomethyl)-2-fluorobenzonitrile 
• 368426-86-2 5-(aminomethyl)-2-fluorobenzonitrile 
• 180302-35-6 5-bromomethyl-2-fluorobenzonitrile 
• 64113-84-4 2-fluoro-5-methylbenzonitrile 
• 368426-87-3 (3-cyano-4-fluoro-benzyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-bicyclic arginine surrogates

Novel, potent, and highly selective classes of thrombin inhibitors were identified, which resulted from judicious combination of P4-aromatics and P2-P3-heterocyclic dipeptide surrogates with weakly basic (calcd pKa ～non-basic - 8.6) bicyclic P1-arginine mimics. The design, synthesis, and biological activity of achiral, non-covalent, orally bioavailable inhibitors NC1-NC44 featuring P1-indazoles, benzimidazoles, indoles, benzotriazoles, and aminobenzisoxazoles is disclosed.