36844-51-6

Usage

Chemical Properties

Pink, orange-reddish low melting solid

Upstream product

• 27914-60-9 4-allyloxybenzoic acid 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 5443-37-8 ethyl 4-(n-prop-2'-enyloxy)benzoate 
• 99-96-7 4-hydroxy-benzoic acid 

Downstream Products

• 69819-27-8 4-allyloxy-N-(5-nitro-thiazol-2-yl)-benzamide 
• 75570-63-7 N-methyl-N-[2-(N',N'-dimethylamino)cyclohexyl]-2-methyl-4-allyloxybenzamide 
• 139233-26-4 4-Allyloxy-N-benzothiazol-2-yl-benzamide 
• 83231-12-3 4-Allyloxy-benzoic acid 3-tert-butylamino-2-hydroxy-propyl ester 
• 119049-08-0 C₂₄H₂₀O₆ 
• 93001-02-6 (S)-4'-<(2-methyl-1-butoxy)carbonyl>biphenyl-4-yl 4-(allyloxy)benzoate 
• 96326-97-5 5-(4-Allyloxy-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid methyl ester 
• 94459-01-5 4-<<4-(allyloxy)benzoyl>oxy>-4'-methoxy-p-terphenyl 
• 73376-32-6 <4-(allyloxy)benzoyloxy>-4-methoxybenzene 

Relevant academic research and scientific papers

Mesomorphic properties of chiral three-arm liquid crystals containing 1,2,4-butanetriol as core

A series of symmetric and asymmetric three-arm liquid crystals (TALCs) of which the molecular structure with a central core of 1, 2, 4-butanetriol attached by three rod-like mesogenic moieties have successfully been synthesized. The rod-like mesogenic sid

Full-spectrum selective reflection annular side chain liquid crystal oligomer film and preparation method thereof

The invention discloses a full-spectrum selective reflection annular side chain liquid crystal oligomer film and a preparation method thereof. The preparation method comprises the following steps: respectively carrying out graft copolymerization on a chiral liquid crystal monomer and an achiral rod-like monomer or two chiral liquid crystal monomers and annular polymethyl hydrogen-containing siloxane to construct the full-spectrum selective reflection annular side chain liquid crystal oligomer film, the structural formula is shown as a formula I. The cyclic side chain liquid crystal oligomer can realize full-spectrum selective reflection in the heating process; at room temperature, the annular side chain liquid crystal oligomer film can realize full-spectrum selective reflection along with the change of an incident angle. The cyclic side chain liquid crystal oligomer prepared by the method has dual characteristics that dynamic full-spectrum selective reflection changes along with temperature and incident angle, and has a wide application prospect in the optical field, the preparation process is safe to operate, and reaction conditions are mild.

Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine

Convenient domino protocol was developed for the synthesis of 2-arylquinazolin-4-amines by the reaction of N-(2-cyanophenyl) substituted benzimidoyl isothiocyanates with isopropyl amine. The major advantages of this protocol are short reaction times, mild conditions, simple work up, high yields, and pure products. The efficacy of this protocol owes to the competence of synthesis, pure isolation of imidoyl isothiocyanates, and the unique structure conformation of the corresponding intermediate thiourea derivatives.

Modified allyl compound, modified bismaleimide prepolymer and application thereof

The present invention provides a modified allyl compound, a modified bismaleimide prepolymer and application thereof, the modified allyl compound is represented by a formula (1), the modified allyl compound has a cyclopentadiene structure represented by a

Modified allyl compound, bismaleimide prepolymer and application thereof

The present invention provides a modified allyl compound, a bismaleimide prepolymer and application thereof, the modified allyl compound is represented by a formula (1), R1 is adopted as a symmetric center, and two symmetric high-rigidity aromatic heteroc

Cholesteric fluorescent liquid crystal polysiloxanes with different liquid crystal side chain lengths—Synthesis and properties

With polymethylhydrogensiloxane (PMHS) as the main chain, two series side-chain cholesteric liquid crystal polymers (ChLCPs) with different liquid crystal side chain lengths were prepared by hydrosilylation reaction. Then two series of cholesteric fluorescent liquid crystal polymers (FL-ChLCPs) were obtained by etherification reaction. The obtained FL-ChLCPs have both excellent mesomorphic behavior, and great photoluminescent property. We confirmed their chemical structures by FT-IR, and 1H NMR spectroscopy, and found them with excellent thermal stability by TGA. We characterized their mesomorphic behavior and thermal performance by POM, DSC and XRD, and confirmed all the polymers belonged to cholesteric phase. FL-ChLCPs emitted different-intensity fluorescence under UV light, and we found some regularity by PL spectrum.

Enantioselective Synthesis of 3-Fluorochromanes via Iodine(I)/Iodine(III) Catalysis

The chromane nucleus is common to a plenum of bioactive small molecules where it is frequently oxidized at position 3. Motivated by the importance of this position in conferring efficacy, and the prominence of bioisosterism in drug discovery, an iodine(I)/iodine(III) catalysis strategy to access enantioenriched 3-fluorochromanes is disclosed (up to 7:93 e.r.). In situ generation of ArIF2 enables the direct fluorocyclization of allyl phenyl ethers to generate novel scaffolds that manifest the stereoelectronic gauche effect. Mechanistic interrogation using deuterated probes confirms a stereospecific process consistent with a type IIinv pathway.

Tubulin inhibitors: Discovery of a new scaffold targeting extra-binding residues within the colchicine site through anchoring substituents properly adapted to their pocket by a semi-flexible linker

Bis-hydrazides 13a-h were designed and synthesized as potential tubulin inhibitors selectively targeting the colchicine site between α- and β-tubulin subunits. The newly designed ring-B substituents were assisted at their ends by ‘anchor groups’ which are expected to exert binding interaction(s) with new additional amino acid residues in the colchicine site (beyond those amino acids previously reported to interact with reference inhibitors as CA-4 and colchicine). Conformational flexibility of bis-hydrazide linker assisted these ‘extra-binding’ properties through reliving ligands’ strains in the final ligand-receptor complexes. Compound 13f displayed the most promising computational and biological study results in the series: MM/GBSA binding energy of ?62.362 kcal/mol (extra-binding to Arg α:221, Thr β:353 & Lys β:254); 34% NCI-H522 cells’ death (at 10 μM), IC50 = 0.073 μM (MTT assay); significant cell cycle arrest at G2/M phase; 11.6% preG1 apoptosis induction and 83.1% in vitro tubulin inhibition (at concentration = IC50). Future researchers in bis-hydrazide tubulin inhibitors are advised to consider the 2-chloro-N-(4-substituted-phenyl)acetamide derivatives as compound 13f due to extra-binding properties of their ring B.

Concise total synthesis of acylated phenolic glycosides vitexnegheteroin A and ovatoside D

Starting from readily available vanillin and α-D-acetobromo glucose, two natural acylated phenolic glycosides vitexnegheteroin A and ovatoside D were synthesized for the first time in 4 steps with overall yields of 54% and 65%, respectively. The key steps involve the directly regioselective O-6 acylation of vanillin β-D-glucopyranoside with acyl chlorides, and simultaneous removal of the allyl protecting groups on the phenolic acid moiety and reduction of the aldehyde in the aglycon moiety by using Pd(PPh)3-NaBH4 system in one pot.

TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS

The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end at least one of a Von Hippel-Lindau ligand, a cereblon ligand, Inhibitors of Apoptosis Proteins ligand, mouse double-minute homolog 2 ligand, or a combination thereof, which binds to the respective E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.