36847-99-1Relevant academic research and scientific papers
Fast thiol-maleamic methyl ester addition for facile covalent cross-linking of oligonucleotides
Cao, Liqiang,Xi, Zhen
supporting information, p. 1916 - 1920 (2013/04/23)
Thiol-Michael-cross-linked oligodeoxynucleotides were synthesized through the thiol-maleamic acid methyl ester addition reaction. As a metal-free 'click' reaction, the cross-linked method was fast responsive and highly sensitive. The newly synthesized oligodeoxynucleotides were thermally stable and their global structures retained those of non-cross-linked oligodeoxynucleotides and showed responsive reaction to different DNA restriction enzymes.
