3685-51-6Relevant academic research and scientific papers
Process for the biotechnological preparation of L-thienylalanines in enantiomerically pure form from 2-hydroxy-3-thienylacrylic acids and their use
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, (2008/06/13)
Process for the biotechnological preparation of L-thienylalanines in enantiomerically pure form from 2-hydroxy-3-thienylacrylic acids, and their use. L-Thienylalanines are prepared via the hydantoin or the azlactone route. The starting substances used for the biotransformation are 2-hydroxy-3-thienylacrylic acids. The innovative step consists in the transamination of the enol form of the 2-hydroxy-3-thienylacrylic acids to give L-thienylalanines with the aid of biotransformation. The transaminiation is carried out in the presence of L-aspartic acid or L-glutamic acid as amino donor.
Asymmetric synthesis of L-thienylalanines
Meiwes, Johannes,Schudok, Manfred,Kretzschmar, Gerhard
, p. 527 - 536 (2007/10/03)
L-Thienylalanines were prepared via the hydantoin and azlactone routes with the key step consisting of the microbial transamination of 2-hydroxy-3-thienylacrylic with L-aspartic acid as amino donor.The transamination reaction was performed by a genetically engineered E. coli strain on scales up to 100 g of L-3-(2-thienyl)alanine 1a and is also applicable to the preparation of the isomeric amino acid 1b and some ring-substituted derivatives.
Studies on Cyclic Dipeptides, I: Aryl Modifications of cyclo-[Phe-His]
Noe,Weigand,Pirker
, p. 1081 - 1097 (2007/10/03)
Seven new cyclic dipeptides have been synthesized and tested for their applicability as tools to elucidate the mechanism of formation of mandelonitrile with (SS)-cyclo-[Phe-His] type catalysts. Conformational analyses based on 1H NMR spectra are presented for all prepared cyclic dipeptides.
