3686-58-6 Usage
Originator
Tolycaine
Hydrochloride,ZYF Pharm Chemical
Manufacturing Process
A suspension of 40 g 2-amino-3-methylbenzoic acid methyl ester in 125 ml of
benzene was added 125 ml of saturated solution of sodium acetate and then
at 0-5°C was added 37 g chloracetylchloride. The mixture was stirred for 1
hour at room temperature. The mixture was filtered. The organic layer was
with 10% solution of potassium carbonate and dries under calcium chloride.
By distillation of the mixture was obtained 15 g of 2-(2-chloroacetylamino)-3-methylbenzoic acid methyl ester; melting point 86-87.5°C (crystallization from
a mixture acetic acid and ligroin); yield 21.8 g.
A mixture of 16 g of 2-(2-chloroacetylamino)-3-methylbenzoic acid methyl
ester and 10 g diethyl amine in benzene was refluxed for 5 hours. After
cooling the diethyl amine hydrochloride was deleted by filtration. The organic
layer was washed with 2 N hydrochloric acid. To the solution was added
potassium carbonate. The product was extracted with ether and distilled.
Brand name
Tolycaine Hydrochloride is
JAN.
Therapeutic Function
Local anesthetic
Check Digit Verification of cas no
The CAS Registry Mumber 3686-58-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,6,8 and 6 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 3686-58:
(6*3)+(5*6)+(4*8)+(3*6)+(2*5)+(1*8)=116
116 % 10 = 6
So 3686-58-6 is a valid CAS Registry Number.
InChI:InChI=1/C15H22N2O3/c1-5-17(6-2)10-13(18)16-14-11(3)8-7-9-12(14)15(19)20-4/h7-9H,5-6,10H2,1-4H3,(H,16,18)
