3687-28-3

Basic information

• Product Name: 3,5-dimethoxybiphenyl-4-ol
• Synonyms: (1,1'-Biphenyl)-4-ol, 3,5-dimethoxy-
• CAS NO: 3687-28-3
• Molecular Formula: C₁₄H₁₄O₃
• Molecular Weight: 230.2592
• Mol File: 3687-28-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 349.4°C at 760 mmHg
• Flash Point: 165.1°C
• Density: 1.144g/cm³
• Vapor Pressure: 2.34E-05mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: 3,5-dimethoxybiphenyl-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dimethoxybiphenyl-4-ol(3687-28-3)
• EPA Substance Registry System: 3,5-dimethoxybiphenyl-4-ol(3687-28-3)

Safety Data

• Hazardous Substances Data: 3687-28-3(Hazardous Substances Data)

Upstream product

• 125106-77-6 2-(benzyloxy)-5-bromo-1,3-dimethoxybenzene 
• 70654-71-6 4-bromo-2,6-dimethoxyphenol 
• 634-36-6 1,2,3-trimethoxybenzene 
• 5150-42-5 2,3-dimethoxyphenol 
• 98-80-6 phenylboronic acid 
• 57197-26-9 5,6,6-trimethoxycyclohexa-2,4-dien-1-one 
• 91-10-1 1,3-dimethoxy-2-hydroxy-benzene 
• 50816-75-6 5-phenyl-1,2,3-trimethoxybenzene 
• 7028-41-3 5-phenylresorcinol 
• 493-72-1 5-phenyl-cyclohexane-1,3-dione 
• 64326-17-6 3,5-dimethoxybiphenyl 

Downstream Products

• 6249-27-0 3,4,5-Trihydroxy-biphenyl 

Relevant articles and documents

Palladium-catalyzed regioselective synthesis of oxygenated biphenyls

Palladium-catalyst-mediated Michael addition reaction of arylboronic acids to cyclohexa-2,4-dienones followed by aromatization sequence in one-pot furnished several oxygenated biphenyl derivatives. Application of the developed methodology was successfully

Suzuki-Miyaura coupling of halophenols and phenol boronic acids: Systematic investigation of positional isomer effects and conclusions for the synthesis of phytoalexins from pyrinae

The Suzuki-Miyaura couplings of o-, m-, and p-halophenols with o-, m-, and p-phenol boronic acids were investigated for all combinations under standardized conditions, using Pd/C as a heterogeneous catalyst and water as a solvent. In the case of iodophenols, conventional heating was used, while for bromophenols significantly better results could be obtained using microwave irradiation. This systematic study revealed that 2,4′-biphenol is particularly difficult to access, irrespective of the starting materials used, but that these difficulties can be overcome by using different additives. The conclusions drawn from this investigation allowed us to identify conditions for the protecting group-free or minimized total synthesis of biaryl-type phytoalexins. These compounds possess antibacterial activity and are produced by fruit trees as a response to microbial infection.