368836-71-9Relevant academic research and scientific papers
NOVEL COMPOUNDS FOR MODULATING CELL PROLIFERATION
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Page/Page column 90, (2008/06/13)
Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.
Tyrenes: Synthesis of new antiproliferative compounds with an extended conjugation
Demin, Peter,Rounova, Olga,Grunberger, Thomas,Cimpean, Lorand,Sharfe, Nigel,Roifman, Chaim M.
, p. 3019 - 3026 (2007/10/03)
A series of substituted styryl-acrylonitriles was designed and synthesized. The new compounds, called tyrenes, were tested for the ability to inhibit acute lymphocytic leukemia (ALL) cancer cell growth, as well as on their toxicity to normal bone marrow (NBM) cells. The results showed that 3,4-dihydroxystyryl- acrylonitriles, in particular CR-4, revealed great potency as antitumor agents, and also exhibited low toxicity to normal cells. The effectiveness of these compounds with extended conjugation may be due to their possible functioning as reactive Michael acceptors.
