368879-84-9Relevant academic research and scientific papers
5- substituted tetralones as inhibitors of ras farnesyl trransferase
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, (2008/06/13)
The present invention provides novel 5-substituted tetralones of Formulas (I), (II), (III) and (IV) and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme.
Method for treating Alzheimer's disease
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, (2008/06/13)
The present invention provides methods and compositions for inhibiting Aβ synthesis and for treating Alzheimer's disease by administering a farnesyl transferase inhibitor of the formula: wherein R is hydrogen, alkyl, and substituted alkyl; R1 i
