368883-65-2Relevant academic research and scientific papers
Alkylation-Terminated Catellani Reactions Using Alkyl Carbagermatranes
Jiang, Wei-Tao,Xiao, Bin,Xie, Xiu-Ying,Xu, Meng-Yu,Yang, Shuo
, p. 20450 - 20454 (2020)
The Catellani reaction has received substantial attention because it enables rapid multiple derivatization on aromatics. While using alkyl electrophiles to achieve ortho-alkylation was one of the earliest applications of the Catellani reaction, ipso-alkyl
5- substituted tetralones as inhibitors of ras farnesyl trransferase
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, (2008/06/13)
The present invention provides novel 5-substituted tetralones of Formulas (I), (II), (III) and (IV) and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme.
