368884-36-0

Basic information

• Product Name: methyl 3-{[(2-{[(1S)-2-(1H-imidazol-1-yl)-1-phenylethyl]oxy}-5-oxo-5,6,7,8-tetrahydro-1-naphthalenyl)methyl]sulfonyl}benzoate
• Synonyms: methyl 3-{[(2-{[(1S)-2-(1H-imidazol-1-yl)-1-phenylethyl]oxy}-5-oxo-5,6,7,8-tetrahydro-1-naphthalenyl)methyl]sulfonyl}benzoate
• CAS NO: 368884-36-0
• Molecular Weight: 544.628
• Mol File: 368884-36-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 3-{[(2-{[(1S)-2-(1H-imidazol-1-yl)-1-phenylethyl]oxy}-5-oxo-5,6,7,8-tetrahydro-1-naphthalenyl)methyl]sulfonyl}benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-{[(2-{[(1S)-2-(1H-imidazol-1-yl)-1-phenylethyl]oxy}-5-oxo-5,6,7,8-tetrahydro-1-naphthalenyl)methyl]sulfonyl}benzoate(368884-36-0)
• EPA Substance Registry System: methyl 3-{[(2-{[(1S)-2-(1H-imidazol-1-yl)-1-phenylethyl]oxy}-5-oxo-5,6,7,8-tetrahydro-1-naphthalenyl)methyl]sulfonyl}benzoate(368884-36-0)

Safety Data

• Hazardous Substances Data: 368884-36-0(Hazardous Substances Data)

Upstream product

• 59604-13-6 -5-chloromethyl-6-hydroxy-3,4-dihydro-2H-napthalen-1-one 
• 72886-42-1 methyl 3-sulfanylbenzoate 
• 368884-37-1 methyl 3-(2-hydroxy-5-oxo-5,6,7,8-tetrahydro-1-naphthalenyl)methylsulfonylbenzoate 
• 27656-18-4 (R)-2-imidazol-1-yl-1-phenyl-ethanol 
• 1972-28-7 diethylazodicarboxylate 

Relevant articles and documents

5- substituted tetralones as inhibitors of ras farnesyl trransferase

The present invention provides novel 5-substituted tetralones of Formulas (I), (II), (III) and (IV) and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme.