36898-42-7

Usage

InChI:InChI=1/C10H6ClNO4S/c11-17(15,16)8-3-1-7(2-4-8)12-9(13)5-6-10(12)14/h1-6H

Upstream product

• 941-69-5 N-phenyl-maleimide 
• 555-59-9 N-phenylmaleamic acid 

Downstream Products

• 114235-06-2 4-(3,5-dioxo-10-oxa-4-azatricyclo[5.2.1.0^2,6]dec-8-en-4-yl)benzenesulfonyl chloride 
• 114234-98-9 endo-N-(p-chlorosulfonylphenyl)norbornenosuccinimide 
• 104924-25-6 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-N,N-dimethyl-benzenesulfonamide 
• 113297-15-7 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-N,N-diethyl-benzenesulfonamide 
• 114235-13-1 N-(p-chlorosulfonylphenyl)-cis-1,2,3,6-4,5-dimethylphthalimide 
• 36898-39-2 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-N-phenyl-benzenesulfonamide 
• 114235-41-5 N-(p-chlorosulfonylphenyl)-3,4,5,6,8,8-hexachlorobicyclo<2.2.1>hept-4-eno succinimide 
• 37559-42-5 N-(p-N'-trichloromethylthio N'-phenylsulfamoylphenyl)maleimide 
• 114235-17-5 C₁₆H₁₉N₃O₄S 

Relevant academic research and scientific papers

Sulfonyl fluoride-based prosthetic compounds as potential 18F labelling agents

Nucleophilic incorporation of [18F]F- under aqueous conditions holds several advantages in radiopharmaceutical development, especially with the advent of complex biological pharmacophores. Sulfonyl fluorides can be prepared in water

Synthesis of new succinimides and sulphonated derivatives with analgesic action in mice

Recently, we have investigated the chemistry and biology of cyclic imides and have used phyllanthimide to obtain several analogues such as maleimides, succinimides and related compounds, which have demonstrated analgesic activity, amongst other properties. The work presented here describes the synthesis of new succinimides and their sulphonated derivatives. These substances were confirmed as having analgesic activity through abdominal constriction tests in mice. The results showed that some of the compounds, given intraperitoneally at a dose of 10 mg kg-1, were more effective than aspirin and paracetamol.

REACTIONS OF N-(p-CHLOROSULFONYLPHENYL)MALEIMIDE

N-Phenylmaleimide reacted with chlorosulfonic acid to give an excellent yield of the sulfonyl chloride (1), which with dimethylamine or aniline (2 equivs.) afforded the corresponding sulfonamides (2,3).However, use of more dimethylamine (4 equivs.) caused