36902-22-4 Usage
Uses
Used in Chemical Biology and Biochemistry Research:
3-Methyl-3H-diazirine-3-ethanamine is utilized as a photoaffinity labeling reagent for studying protein-ligand interactions. Its photoreactive properties allow for the identification of binding sites, which is instrumental in understanding the molecular mechanisms of various biological processes.
Used in Photo-crosslinking Experiments:
In the field of molecular biology, 3-Methyl-3H-diazirine-3-ethanamine is used as a crosslinking agent to probe specific protein-protein interactions. This application aids researchers in elucidating the structural and functional aspects of biomolecules, contributing to a deeper comprehension of cellular and molecular biology.
Check Digit Verification of cas no
The CAS Registry Mumber 36902-22-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,9,0 and 2 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 36902-22:
(7*3)+(6*6)+(5*9)+(4*0)+(3*2)+(2*2)+(1*2)=114
114 % 10 = 4
So 36902-22-4 is a valid CAS Registry Number.
36902-22-4Relevant academic research and scientific papers
Chemical Synthesis of Diubiquitin-Based Photoaffinity Probes for Selectively Profiling Ubiquitin-Binding Proteins
Liang, Jun,Zhang, Lin,Tan, Xiang-Long,Qi, Yun-Kun,Feng, Shan,Deng, Haiteng,Yan, Yijing,Zheng, Ji-Shen,Liu, Lei,Tian, Chang-Lin
supporting information, p. 2744 - 2748 (2017/02/26)
Biochemical studies of cellular processes involving polyubiquitin have gained increasing attention. More tools are needed to identify ubiquitin (Ub)-binding proteins. We report diazirine-based photoaffinity probes that can capture Ub-binding proteins in c
Diazirine-based DNA photo-cross-linking probes for the study of protein-DNA interactions
Shigdel, Uddhav Kumar,Zhang, Junliang,He, Chuan
, p. 90 - 93 (2008/09/19)
(Figure Presented) Small modification, large effect: Diazirine can be installed quickly and simply in the major or minor groove of DNA for efficient photo-cross-linking to proteins (see picture). This method should be suitable for mapping out protein-DNA interactions, in particular those that may be sensitive to steric hindrance.
