36909-95-2

Usage

Functionality

Used in the synthesis of various organic compounds

Application

Production of pharmaceuticals and agrochemicals

Chemical Structure

Dichloride derivative of cyclohexanedicarboxylic acid

Role

Commonly used as a building block in organic synthesis

Reactivity

Acts as a reactive intermediate in the production of many useful organic molecules

Safety Precaution

Can be corrosive and toxic if not handled properly

Importance

Essential in the creation of various organic molecules for different industries

Upstream product

• 2305-32-0 trans-1,2-cyclohexanedicarboxylic acid 

Downstream Products

• 115720-23-5 (+/-)-trans-1-cyano-cyclohexane-carboxylic acid-(2) 
• 90682-77-2 (3E,9E)-1,2-Diphenyl-3,10-bis-trimethylsilanyloxy-1,2,5,6,7,8-hexahydro-[1,2]diphosphecine 
• 104722-26-1 trans-1,2-dibenzoylcyclohexane 

Relevant academic research and scientific papers

Rational tuning chelate size of bis-oxazoline ligands to improve enantioselectivity in the asymmetric aziridination of chalcones

Chalcones were asymmetrically aziridinated with [N-(p-toluenesulfonyl) imino]phenyliodinane (PhI=NTs) as a nitrene source under catalysis of CuOTf and a series of cyclohexane-linked bis-oxazolines (cHBOXes), which are chelate size rationally tuned bis-oxazolines. The results indicate that highly enantioselective aziridination of chalcones with up to >99% ee have been achieved under catalysis of (S,S)-1,2-bis[(S)-(4-phenyl)oxazolin-2-yl] cyclohexane, which is the most-matched stereoisomer among cyclohexane-linked bis-oxazolines. It was also found that the enantioselectivity is not substituent-dependent with respect to chalcones in the present case, unlike with 1,8-anthracene-linked bis-oxazolines (AnBOXes).