36919-48-9Relevant academic research and scientific papers
2-Bromo[6]helicene as a Key Intermediate for [6]Helicene Functionalization
Jakubec, Martin,Beránek, Tomá?,Jakubík, Pavel,Sykora, Jan,?ádny, Jaroslav,Církva, Vladimír,Storch, Jan
, p. 3607 - 3616 (2018/04/14)
The synthesis of 2-bromo[6]helicene was revised and improved up to 51% yield. Its reactivity was thoroughly investigated, and a library of 17 different carbon, boron, nitrogen, phosphorus, oxygen and sulfur substituted derivatives was prepared. The racemization barrier for 2-bromo[6]helicene was determined, and the usage of enantiomers in the synthesis of optically pure helicenes was rationalized. The three most energy-demanding reactions using enantiomerically pure 2-bromo[6]helicene were tested in order to confirm the predicted enantiomeric excess.
