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3693-39-8

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  • Pregna-1,4-diene-3,20-dione, 9,11-dichloro-6-fluoro-21-hydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-

    Cas No: 3693-39-8

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  • Pregna-1,4-diene-3,20-dione, 9,11-dichloro-6-fluoro-21-hydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-

    Cas No: 3693-39-8

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3693-39-8 Usage

Description

Fluclorolone acetonide is a synthetic glucocorticoid characterized by its potent anti-inflammatory properties. It has been found to effectively inhibit mouse skin tumor promotion and epidermal DNA synthesis, making it a promising candidate for pharmaceutical applications.

Uses

Used in Pharmaceutical Industry:
Fluclorolone acetonide is used as an anti-inflammatory agent for its ability to inhibit inflammation and reduce swelling. Its potent inhibitory effects on mouse skin tumor promotion and epidermal DNA synthesis also suggest potential applications in cancer treatment and prevention.
Used in Dermatological Applications:
In the field of dermatology, fluclorolone acetonide is used as a topical treatment for various skin conditions, including eczema, psoriasis, and other inflammatory skin disorders. Its anti-inflammatory properties help to alleviate redness, itching, and swelling associated with these conditions.
Used in Oncological Applications:
Fluclorolone acetonide's potential as a potent inhibitor of mouse skin tumor promotion and epidermal DNA synthesis indicates its possible use in oncology for the prevention and treatment of skin cancers. Further research is needed to explore its full potential in this area.

Originator

Topilar,Syntex,UK,1971

Manufacturing Process

To 6α-fluoro-16α-hydroxy-hydrocortisone 21-acetate, described by Mills et al, J. Am. Chem. Soc., volume 81, pages 1264 to 1265, March 5, 1959, there was added acetic anhydride in dry pyridine. The reaction mixture was left at room temperature overnight and was then poured with stirring into ice water. The resulting precipitate was filtered, washed with water and crystallized from acetone-hexane to give 6α-fluoro-16α-hydroxy-hydrocortisone-16α,21- diacetate. This was reacted with methane-sulfonyl chloride in dimethyl formamide in the presence of pyridine at 80°C for 1 hour. The mixture was cooled, diluted with water and extracted with ethyl acetate. The extract was washed with water, dried over anhydrous sodium sulfate and the ethyl acetate was evaporated. By recrystallization of the residue from acetone-hexane there was obtained 6α-fluoro-Δ4,9(11)-pregnadiene-16α,17α,21-triol-3,20-dione- 16α,21-diacetate.This was reacted with chlorine to give the dichloropregnene compound, then with selenium dioxide to give the dichloropregnadiene compound. By hydrolysis with methanolic potassium hydroxide there was obtained the free 6α-fluoro-9α,11β-dichloro-Δ1,4-pregnadiene-16α,17α,21-triol-3,20-dione. By treatment with acetone in the presence of perchloric acid, the 16,17-acetonide of 6α-fluoro-9α,11β-dichloro-Δ1,4-pregnadiene-16α,17α,21-triol-3,20-dione was formed.

Therapeutic Function

Glucocorticoid

Check Digit Verification of cas no

The CAS Registry Mumber 3693-39-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,6,9 and 3 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 3693-39:
(6*3)+(5*6)+(4*9)+(3*3)+(2*3)+(1*9)=108
108 % 10 = 8
So 3693-39-8 is a valid CAS Registry Number.
InChI:InChI=1/C24H29Cl2FO5/c1-20(2)31-19-9-13-14-8-16(27)15-7-12(29)5-6-21(15,3)23(14,26)17(25)10-22(13,4)24(19,32-20)18(30)11-28/h5-7,13-14,16-17,19,28H,8-11H2,1-4H3/t13?,14?,16-,17?,19+,21?,22?,23-,24+/m0/s1

3693-39-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Flucloronide

1.2 Other means of identification

Product number -
Other names FLUCLORONIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3693-39-8 SDS

3693-39-8Upstream product

3693-39-8Downstream Products

3693-39-8Relevant articles and documents

Method for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor

-

, (2008/06/13)

Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.

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