36937-89-0

Upstream product

• 447-61-0 2-Trifluoromethylbenzaldehyde 
• 109-77-3 malononitrile 

Downstream Products

• 304880-15-7 2-amino-7,7-dimethyl-5-oxo-4-(2-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile 
• 122165-13-3 2-(o-trifluoromethyl)phenyl-1,1,2-tricyanoethylene 
• 1431621-39-4 6-amino-1-((1,3-diphenyl-1H-pyrazol-4-yl)methyleneamino)-2-oxo-4-(2 (trifluoromethyl)phenyl)-1,2-dihydropyridine-3,5-dicarbonitrile 
• 122165-18-8 2-(o-trifluoromethyl)phenyl-1,1,2-tricyanoethane 

Relevant academic research and scientific papers

Phosphorous acid functionalized polyacrylonitrile fibers with a polarity tunable surface micro-environment for one-pot C-C and C-N bond formation reactions

The preparation and application of fiber catalysts have attracted much attention. However, research on the effect of the micro-environment of fiber catalysts on the catalytic activities though of special importance is limited. In this work, a novel strategy for the synthesis of phosphoric acid-functionalized polyacrylonitrile fibers with a polarity tunable surface micro-environment by hydrophobic groups for one-pot C-C and C-N bond formation reactions is reported. The special hydrophobic surface micro-environment of the fiber catalysts is proven to promote the catalytic activities impressively in cyclocondensation of β-ketoesters with 2-aminobenzamides, the Knoevenagel condensation as well as the multi-component Biginelli reactions in green solvents. Both the surface synergy of the catalytic sites and hydrophobic auxiliary groups (benzyl or n-butyl) in the surface of fiber catalysts and interface acceleration in reaction medium play an important role in the highly efficient promotion of catalytic activity. Thereby a surface synergistic mechanism is proposed to explain the micro-environment effect. In addition, the fiber catalysts could be simply separated from the reaction system using tweezers and directly used in the next cycle without further treatment. Importantly, even after 10 reaction cycles in water or ethanol, there is no significant loss in their catalytic activity. The results indicate that the phosphoric acid functionalized fibers show green and sustainable potential for industrial production.

Knoevenagel condensation catalyzed by a tertiary-amine functionalized polyacrylonitrile fiber

A new fiber catalyst for Knoevenagel condensation has been prepared by aminating a commercially available polyacrylonitrile fiber with N,N-dimethyl-1,3-propanediamine. The fiber catalyst was characterized by elemental analysis, X-ray powder diffraction spectra (XRD), scanning electron microscopy (SEM) and Fourier-transfer infrared spectroscopy (FTIR). The Knoevenagel condensation proceeded smoothly in the presence of the fiber catalyst and the products were obtained in excellent yields. This catalyst is applicable to a wide range of aromatic aldehydes. Moreover, the reaction can be easily carried out in different solvents of varying polarities. The newly developed fiber catalyst was also found to exhibit excellent recyclability and reusability (up to 10 times) without any additional treatment.

New multipotent tetracyclic tacrines with neuroprotective activity

The synthesis and the biological evaluation (neuroprotection, voltage dependent calcium channel blockade, AChE/BuChE inhibitory activity and propidium binding) of new multipotent tetracyclic tacrine analogues (5-13) are described. Compounds 7, 8 and 11 sh

Synthesis of substituted 6-amino-4-aryl-5-cyano-2h,4h-pyrano[2,3-c]pyrazoles. Crystal and molecular structure of 6-amino-5-cyano-3-methyl-4-(2′,4′,6′-triethylphenyl)-2h,4h -pyrano[2,3-c]pyrazole

Substituted 6-aminopyrano[2,3-c]pyazoles were synthesized by the two-component condensation of arylidenemalononitriles and substituted 5-pyazolones or three-component condensation of aromatic aldehydes, malononitrile, and substituted 5-pyazolones. It was

Therapy for diabetic complications

This invention provides a method of treating diabetic complications in mammals which comprises the administration of a compound of the Formula I: STR1 in which n, R1, R2, R3, and R4 are variables.

METAL COMPLEXES OF FLUORINE-SUBSTITUTED TETRACYANOTETRAARYLPORPHYRAZINES

Magnesium, copper, vanadyl, and cobalt complexes of tetracyanoporphyrazines containing four fluorine-substituted benzene rings were synthesized from tricyanethylenes containing pentafluorophenyl, o-trifluoromethylphenyl, and o-hexafluoropropoxyphenyl radicals.The magnesium complex of tetracyanoporphyrazine containing the N(C2H5)CH2CF2CHF2 group at the para position of the benzene ring was obtained.