369377-97-9

Upstream product

• 369377-88-8 2-(6-chloropyridin-2-yl)prop-2-enyl acetate 
• 369377-91-3 (R)-2-(6-chloropyridin-2-yl)-2,3-epoxypropanol 
• 369377-89-9 2-(6-chloropyridin-2-yl)prop-2-en-1-ol 
• 118775-50-1 2-chloro-6-(1-chloromethylvinyl)pyridine 
• 110-87-2 3,4-dihydro-2H-pyran 
• 369377-94-6 (S)-2-chloro-6-[2-(tetrahydropyran-2-yloxymethyl)oxiran-2-yl]pyridine 

Downstream Products

• 369378-01-8 (R)-3-[(4-chloro-3-methylbenzenesulfonyl)methylamino]-2-(6-chloropyridin-2-yl)-2-hydroxypropyl p-toluenesulfonate 
• 369377-99-1 (R)-4-chloro-N-[2-(6-chloropyridin-2-yl)-2,3-dihydroxypropyl]-3,N-dimethylbenzenesulfonamide 

Relevant academic research and scientific papers

Synthesis of optically active N-(2-pyridyloxiran-2-ylmethyl) benzenesulfonamide derivatives and their herbicidal activity

Novel herbicidally active sulfonamide compounds having a 2-arylsubstituted oxiranylmethyl structure are racemates due to a chiral carbon in the oxirane moiety. To clarify the stereochemical structure-activity relationship, we synthesized each enantiomer of 4-chloro-N-[2-(6-chloropyridin-2-yl)-2-oxiran-2-ylmethyl]-3,N- dimethylbenzenesulfonamide and N-[2-(6-chloropyridin-2-yl)-2-oxiran-2-ylmethyl]-N-methyl-5,6,7,8- tetrahydronaphthalene-2-sulfonamide by chemical methods including Sharpless asymmetric chlorohydroxylation. The results of herbicidal tests indicated that the (S)-isomers were the active forms.