369378-07-4

Upstream product

• 369378-04-1 (S)-N-[2-(6-chloropyridin-2-yl)-2-hydroxy-3-(tetrahydropyran-2-yloxy)propyl]-N-methyl-5,6,7,8-tetrahydronaphthalene-2-sulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 369378-05-2 (S)-N-[2-(6-chloropyridin-2-yl)-2,3-dihydroxypropyl]-N-methyl-5,6,7,8-tetrahydronaphthalene-2-sulfonamide 
• 369377-90-2 (S)-2-(6-chloropyridin-2-yl)-2,3-epoxypropanol 
• 369377-89-9 2-(6-chloropyridin-2-yl)prop-2-en-1-ol 
• 118775-50-1 2-chloro-6-(1-chloromethylvinyl)pyridine 
• 369377-92-4 (R)-2-chloro-6-[2-(tetrahydropyran-2-yloxymethyl)oxiran-2-yl]pyridine 
• 369377-88-8 2-(6-chloropyridin-2-yl)prop-2-enyl acetate 

Relevant academic research and scientific papers

Synthesis of optically active N-(2-pyridyloxiran-2-ylmethyl) benzenesulfonamide derivatives and their herbicidal activity

Novel herbicidally active sulfonamide compounds having a 2-arylsubstituted oxiranylmethyl structure are racemates due to a chiral carbon in the oxirane moiety. To clarify the stereochemical structure-activity relationship, we synthesized each enantiomer of 4-chloro-N-[2-(6-chloropyridin-2-yl)-2-oxiran-2-ylmethyl]-3,N- dimethylbenzenesulfonamide and N-[2-(6-chloropyridin-2-yl)-2-oxiran-2-ylmethyl]-N-methyl-5,6,7,8- tetrahydronaphthalene-2-sulfonamide by chemical methods including Sharpless asymmetric chlorohydroxylation. The results of herbicidal tests indicated that the (S)-isomers were the active forms.