3694-48-2Relevant academic research and scientific papers
Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity
Kumar, Kunal,Man-Un Ung, Peter,Wang, Peng,Wang, Hui,Li, Hailing,Andrews, Mary K.,Stewart, Andrew F.,Schlessinger, Avner,DeVita, Robert J.
supporting information, p. 1005 - 1016 (2018/09/05)
The Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) is an enzyme that has been implicated as an important drug target in various therapeutic areas, including neurological disorders (Down syndrome, Alzheimer's disease), oncology, and
Electron-transfer induced rearrangement of thiocyanate to isothiocyanate
Wakamatsu, Kan,Dairiki, Jun,Etoh, Tetsuo,Yamamoto, Hiroshi,Yamamoto, Satoshi,Shigetomi, Yasumasa
, p. 365 - 369 (2007/10/03)
Benzyl thiocyanates with an electron-withdrawing group (1a, 1b) and 9- fluorenyl thiocyanate (1e) rearrange to the corresponding isothiocyanate (2) under 9,10-diphenylanthracene (DPA) sensitization. The rearrangement would proceed via carbon-sulfur bond cleavage in an anion radical of 1 produced by photoinduced electron transfer, followed by back electron transfer to DPA·+ and recombination of the resulting radical or ion pair.
Substitution Reaction of Organic Halide by Trimethylsilyl Isothiocyanate: Formation of Thiocyanate and Its Rearrangement to Isothiocyanate
Nishiyama, Kozaburo,Oba, Makoto
, p. 2692 - 2694 (2007/10/02)
The reaction of organic halide with trimethylsilyl isothiocyanate (TMSTC) gave thiocyanate 1 and its isomerized isothiocyanate 2.Details of the substitution and the isomerization reactions were examined.
