369403-56-5

Upstream product

• 71721-69-2 ethyl 2-(hydroxyimino)-2-(pyridin-4-yl)acetate 
• 6622-91-9 2-(pyridine-4-yl)acetic acid hydrochloride 
• 313490-99-2 (RS)-ethyl 2-(t-butoxycarbonylamino)-2-(pyridin-4-yl)acetate 
• 54401-85-3 pyridin-4-yl-acetic acid ethyl ester 

Downstream Products

• 1379796-24-3 (RS)-N-benzyl 2-amino-2-(pyridin-4-yl)acetamide oxalate 

Relevant academic research and scientific papers

Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides

N-Benzyl 2-acetamido-2-substituted acetamides, where the 2-substituent is a (hetero)aromatic moiety, are potent anticonvulsants. We report the synthesis and whole animal pharmacological evaluation of 16 analogues where the terminal 2-acetyl group was removed to give the corresponding primary amino acid derivatives (PAADs). Conversion to the PAAD structure led to a substantial drop in seizure protection in animal tests, demonstrating the importance of the N-acetyl moiety for anticonvulsant activity. However, several of the PAADs displayed notable pain-attenuating activities in a mouse model.