369598-88-9Relevant academic research and scientific papers
The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold
Tullis, Joshua S.,Laufersweiler, Matthew J.,VanRens, John C.,Natchus, Michael G.,Bookland, Roger G.,Almstead, Neil G.,Pikul, Stanislaw,De, Biswanath,Hsieh, Lily C.,Janusz, Michael J.,Branch, Todd M.,Peng, Sean X.,Jin, Yingkun Y.,Hudlicky, Tomas,Oppong, Kofi
, p. 1975 - 1979 (2001)
A series of carboxylic acids was prepared based on cyclohexylglycine scaffolds and tested for potency as matrix metalloproteinase (MMP) inhibitors. Detailed SAR for the series is reported for five enzymes within the MMP family, and a number of inhibitors such as compound 18 display low nanomolar potency for MMP-2 and MMP-13, while selectively sparing MMP-1 and MMP-7.
Carbocyclic side chain containing, N-substituted metalloprotease inhibitors
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, (2008/06/13)
The compounds have a structure according to the following Formula (I): are effective in treating conditions characterized by excess activity of metalloprotease enzymes.
Carbocyclic side chain containing metalloprotease inhibitors
-
, (2008/06/13)
The compounds have a structure according to the following Formula (I): are effective in treating conditions characterized by excess activity of these enzymes.
