369609-88-1

Basic information

• Product Name: Propanamide, 3-amino-N-(4-methylphenyl)-3-thioxo-
• CAS NO: 369609-88-1
• Molecular Formula: C10H12N2OS
• Molecular Weight: 208.284
• Mol File: 369609-88-1.mol

Chemical Properties

• CAS DataBase Reference: Propanamide, 3-amino-N-(4-methylphenyl)-3-thioxo-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, 3-amino-N-(4-methylphenyl)-3-thioxo-(369609-88-1)
• EPA Substance Registry System: Propanamide, 3-amino-N-(4-methylphenyl)-3-thioxo-(369609-88-1)

Safety Data

• Hazardous Substances Data: 369609-88-1(Hazardous Substances Data)

Upstream product

• 6876-54-6 2-cyano-N-(4-methylphenyl)acetamide 

Downstream Products

• 1447585-68-3 4-({2-[(2-methoxyphenyl)amino]-2-oxoethyl}thio)-N-(4-methylphenyl)-2-{2-[(4-methylphenyl)amino]-2-oxoethyl}pyrimidine-5-carboxamide 
• 1447585-67-2 4-({2-[(3-methoxyphenyl)amino]-2-oxoethyl}thio)-N-(4-methylphenyl)-2-{2-[(4-methylphenyl)amino]-2-oxoethyl}pyrimidine-5-carboxamide 
• 1447585-66-1 4-({2-[(2-chlorophenyl)amino]-2-oxoethyl}thio)-N-(4-methylphenyl)-2-{2-[(4-methylphenyl)amino]-2-oxoethyl}pyrimidine-5-carboxamide 
• 1447585-65-0 N-(4-methylphenyl)-4-({2-[(4-ethylphenyl)amino]-2-oxo-ethyl}thio)2-{2-[(4-methylphenyl)amino]-2-oxoethyl}pyrimidine-5-carboxamide 
• 1447585-64-9 ethyl 2-({[(5-{[(4-methylphenyl)amino]carbonyl}-2-{2-[(4-methylphenyl)amino]-2-oxoethyl}pyrimidin-4-yl)thio]acetyl}amino)-4,5,6,7-tetrahydro-1-benzo[b]thiophene-3-carboxylate 
• 1447585-63-8 ethyl [(2-{2-[(4-methylphenyl)amino]-2-oxoethyl}-5-[N-(4-methylphenyl)carbamoyl]pyrimidin-4-yl)thio]acetate 
• 1447585-62-7 4-({2-[(4-bromophenyl)amino]-2-oxoethyl}thio)-N-(4-methylphenyl)-2-{2-[(4-methylphenyl)amino]-2-oxoethyl}pyrimidine-5-carboxamide 
• 1447585-56-9 N-(4-methylphenyl)-2-{2-[(4-methylphenyl)amino]-2-oxoethyl}-6-thioxo-1,6-dihydropyrimidine-5-carboxamide 
• 1412453-24-7 piperidinium 6-amino-5-cyano-3-N-(4-methylphenyl)carbamoyl-4-phenyl-1,4-dihydropyridine-2-thiolate 

Relevant articles and documents

Unexpected result in the reaction of 3-amino-3-thioxopropanamides with 2-anilinomethylene derivatives of 1,3-dicarbonyl compounds. synthesis of pyrimidine-5-carboxamide derivatives

The interaction of 3-amino-3-thioxopropanamides with 2-anilinomethylene derivatives of dimedone, 1,3-cyclohexanedione and Meldrum's acid led to the formation of 2-(2-amino-2-oxoethyl)-6-thioxo-1,6-dihydropyrimidine-5- carboxamides. The latter were alkylated in alkaline medium with the formation of 4-(alkylthio)pyrimidine-5-carboxamide derivatives.

The mannich reaction in the synthesis of N,S-containing heterocycles 12.* First example of aminomethylation involving 2-thioxonicotinamide derivative: Synthesis of 3,5,7,11-tetraazatricyclo[7.3.1.02,7]tridec- 2-ene-9-carboxamides

Piperidinium 6-amino-5-cyano-3-N-(4-methylphenyl)carbamoyl-4-phenyl-1,4- dihydro- pyridine-2-thiolate upon the action of primary amines and excess formaldehyde undergoes aminomethylation to form 3,5,7,11-tetraazatricyclo[7.3.1. 02,7]tridec-2-en

E-Z-izomerization of 2-methylenethiazolidin-4-ones

The equilibrium concentrations of E- and Z-isomers of thiazolidin-4-ones containing exocyclic double bonds in positions 2 and 5 of the cycle were determined in DMSO-d6. The influence of the nature of the substituents on the equilibrium position was found. Electron-releasing substituents stabilize the E,Z-configuration and electron-withdrawing substituents stabilize the Z,Z-configuration. The association constants of E- and Z-2-ethoxycarbonylmethylenethiazolidin-4-ones with the sodium cation were determined by 1H NMR spectroscopy.