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(5-Bromomethyl-pyrazin-2-yl)-carbamic acid tert-butyl ester is an ester derivative of carbamic acid featuring a pyrazinyl group with a bromomethyl substituent. (5-Bromomethyl-pyrazin-2-yl)-carbamic acid tert-butyl ester is recognized for its potential pharmaceutical applications and has been investigated for its antimicrobial and pesticidal properties. The tert-butyl ester functional group enhances its stability and reactivity in various chemical reactions, making it a valuable building block in organic synthesis and drug development.

369638-69-7

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  • Carbamic acid,N-[5-(bromomethyl)-2-pyrazinyl]-, 1,1-dimethylethyl ester

    Cas No: 369638-69-7

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369638-69-7 Usage

Uses

Used in Pharmaceutical Industry:
(5-Bromomethyl-pyrazin-2-yl)-carbamic acid tert-butyl ester is used as a building block in the development of new drug molecules due to its unique structure and pharmacological properties. Its potential applications include the creation of antimicrobial and pesticidal agents, contributing to the advancement of treatments for various diseases and pests.
Used in Organic Synthesis:
In the field of organic synthesis, (5-Bromomethyl-pyrazin-2-yl)-carbamic acid tert-butyl ester serves as a versatile intermediate for the synthesis of complex organic compounds. Its reactivity and stability facilitate the formation of a wide range of chemical products, expanding the scope of synthetic chemistry.
Used in Agrochemical Development:
(5-Bromomethyl-pyrazin-2-yl)-carbamic acid tert-butyl ester is utilized in the development of agrochemicals, particularly as a component in the creation of new pesticides. Its antimicrobial and pesticidal properties make it a promising candidate for enhancing crop protection and managing pest infestations in agriculture.

Check Digit Verification of cas no

The CAS Registry Mumber 369638-69-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,9,6,3 and 8 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 369638-69:
(8*3)+(7*6)+(6*9)+(5*6)+(4*3)+(3*8)+(2*6)+(1*9)=207
207 % 10 = 7
So 369638-69-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H14BrN3O2/c1-10(2,3)16-9(15)14-8-6-12-7(4-11)5-13-8/h5-6H,4H2,1-3H3,(H,13,14,15)

369638-69-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl N-[5-(bromomethyl)pyrazin-2-yl]carbamate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:369638-69-7 SDS

369638-69-7Downstream Products

369638-69-7Relevant articles and documents

Aminoheteroaryl benzamides as kinase inhibitors

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, (2016/02/15)

The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

Amido Compounds

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, (2012/06/18)

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein the variables are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

TYPE II RAF KINASE INHIBITORS

-

, (2011/08/08)

The present invention relates to novel compounds which are able to modulate b-raf kinases, and the use of such compounds in the treatment of various diseases, disorders or conditions.

FLUORINATED HETEROARYLS

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Page/Page column 44-45, (2010/04/03)

The present invention provides Formula (1A) XN O R 3 HN R 5 O R 4 R 2 R 1 (1A) 5 compounds that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by the glucokinase enzyme, where X, R 1, R 2, R 3, R 4, and R 5 are as described herein.

SELECTIVE INHIBITORS AGAINST Cdk4 AND Cdk6 HAVING AMINOTHIAZOLE SKELETON

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Page/Page column 32, (2010/11/25)

The present invention relates to a compound represented by Formula [I]: wherein X is O, S, NH or CH 2 ; Y 1 , Y 2 , Y 3 , Y 4 and Y 5 , which may be identical or different, are each CH or N; however, at least one of Y 1 , Y 2 , Y 3 , Y 4 and Y 5 is N; Z 1 and Z 2 , which may be identical or different, are each CH or N; n is an integer from 1 to 3; R 1 is a C 3 -C 8 cycloalkyl group, a C 6 -C 10 aryl group, an aliphatic heterocyclic ring or an aromatic heterocyclic ring, or a bicyclic aliphatic saturated hydrocarbon group; R 2 and R 3 , which may be identical or different, are each a hydrogen atom, a lower alkyl group, a lower alkenyl group, a C 3 -C 8 cycloalkyl group, a C 6 -C 10 aryl group, an aromatic heterocyclic ring, or the like; and R 4 is a hydrogen atom, a lower alkyl group, a C 3 -C 6 cycloalkyl group or the like, or a pharmaceutically acceptable salt or ester thereof, and a selective inhibitor against Cdk4 and/or Cdk6 or an anticancer agent containing the compound or a pharmaceutically acceptable salt or ester thereof.

Identification of potent 5-pyrimidinyl-2-aminothiazole CDK4, 6 inhibitors with significant selectivity over CDK1, 2, 5, 7, and 9

Shimamura, Tadashi,Shibata, Jun,Kurihara, Hideki,Mita, Takashi,Otsuki, Sachie,Sagara, Takeshi,Hirai, Hiroshi,Iwasawa, Yoshikazu

, p. 3751 - 3754 (2007/10/03)

5-Pyrimidinyl-2-aminothiazole 1 was identified as an inhibitor of cyclin-dependent kinases (CDKs) by a screening of the Merck sample repository. The introduction of a methyl group at the C-5 or C-6 position on the pyrimidine ring, directed toward the gate

Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists

Lee, Jeewoo,Kang, Sang-Uk,Kil, Min-Jung,Shin, Myoungyoup,Lim, Ju-Ok,Choi, Hyun-Kyung,Jin, Mi-Kyoung,Kim, Su Yeon,Kim, Sung-Eun,Lee, Yong-Sil,Min, Kyung-Hoon,Kim, Young-Ho,Ha, Hee-Jin,Tran, Richard,Welter, Jacqueline D.,Wang, Yun,Szabo, Tamas,Pearce, Larry V.,Lundberg, Daniel J.,Toth, Attila,Pavlyukovets, Vladimir A.,Morgan, Matthew A.,Blumberg, Peter M.

, p. 4136 - 4142 (2007/10/03)

The structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues have been investigated as TRPV1 receptor antagonists. The 2-halogen analogues showed enhanced antagonism compared to the prototype antagonist.

Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-monocyclic arginine surrogates

Reiner, John E.,Siev, Daniel V.,Araldi, Gian-Luca,Cui, Jingrong Jean,Ho, Jonathan Z.,Reddy, Komandla Malla,Mamedova, Lala,Vu, Phong H.,Lee, Kuen-Shan S.,Minami, Nathaniel K.,Gibson, Tony S.,Anderson, Susanne M.,Bradbury, Annette E.,Nolan, Thomas G.,Semple, J. Edward

, p. 1203 - 1208 (2007/10/03)

Investigations on P2-P3-heterocyclic dipeptide surrogates directed towards identification of an orally bioavailable thrombin inhibitor led us to pursue novel classes of achiral, non-covalent P1-arginine derivatives. The design, synthesis, and biological activity of inhibitors NC1-NC30 that feature three classes of monocyclic P1-arginine surrogates will be disclosed: (1) (hetero)aromatic amidines, amines and hydroxyamidines, (2) 2-aminopyrazines, and (3) 2-aminopyrimidines and 2-aminotetrahydropyrimidines.

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