369640-48-2Relevant academic research and scientific papers
Cyclic imides as potent and selective α-1A adrenergic receptor antagonists
DiPardo, Robert M.,Patane, Michael A.,Newton, Randall C.,Price, RoseAnn,Broten, Theodore P.,Chang, Raymond S.L.,Ransom, Richard W.,Di Salvo, Jerry,Freidinger, Roger M.,Bock, Mark G
, p. 1959 - 1962 (2007/10/03)
We disclose a new compound class of potent and selective α-1A adrenergic receptor antagonists exemplified by the geminally, disubstituted cyclic imide 7. The optimization of lead compounds resulting in the cyclic imide motif is highlighted. The results of in vitro and in vivo studies of selected compounds are presented.
