36983-38-7Relevant academic research and scientific papers
RETRACTED ARTICLE: IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance
Singh, Kumar Sachin,Sharma, Rishabh,Reddy, Poli Adi Narayana,Vonteddu, Prashanthi,Good, Madeline,Sundarrajan, Anjana,Choi, Hyeree,Muthumani, Kar,Kossenkov, Andrew,Goldman, Aaron R.,Tang, Hsin-Yao,Totrov, Maxim,Cassel, Joel,Murphy, Maureen E.,Somasundaram, Rajasekharan,Herlyn, Meenhard,Salvino, Joseph M.,Dotiwala, Farokh
, p. 597 - 602 (2021)
Isoprenoids are vital for all organisms, in which they maintain membrane stability and support core functions such as respiration1. IspH, an enzyme in the methyl erythritol phosphate pathway of isoprenoid synthesis, is essential for Gram-negati
MCL-1 inhibitor as well as preparation method and application thereof
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Paragraph 0048-0052, (2021/03/24)
The invention discloses an MCL-1 inhibitor as well as a preparation method and application thereof. The preparation method comprises the following steps of reacting ethylene oxalate with a compound Acontaining naphthylacetone for 4-6 hours to obtain a com
ISPH INHIBITORS, AND METHODS OF MAKING AND USING SAME
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Page/Page column 30; 34-35, (2021/02/05)
In one aspect, the invention provides novel compounds useful for treating bacterial infections, such as but not limited to Gram-negative bacterial infections. In another aspect, the invention provides novel compounds useful for activating γδ T cell respon
Rational modification, synthesis and biological evaluation of 3,4-dihydroquinoxalin-2(1H)-one derivatives as potent and selective c-Jun N-terminal kinase 3 (JNK3) inhibitors
Dou, Xiaodong,Huang, Huixia,Jiang, Lan,Jiao, Ning,Jin, Hongwei,Liu, Zhenming,Zhang, Liangren,Zhang, Lihe,Zhu, Guiwang
, (2020/07/03)
The c-Jun N-terminal kinase 3 (JNK3) plays key roles in a wide range of diseases, including neurodegeneration diseases, inflammation diseases, cancers, cardiovascular diseases, and metabolic disorders. Previously, we have identified a lead compound, (Z)-3
Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors
Patil, Shivaputra,Kamath, Shantaram,Sanchez, Tino,Neamati, Nouri,Schinazi, Raymond F.,Buolamwini, John K.
, p. 1212 - 1228 (2007/10/03)
A new series of phenanthridinone derivatives, and diketo acid analogs, as well as related phenanthrene and anthracene diketo acids have been synthesized and evaluated as HIV integrase (IN) inhibitors. Several new β-diketo acid analogs with the phenanthrid
