3699-83-0

Basic information

• Product Name: Phosphonic acid, [2-oxo-2-(phenylamino)ethyl]-, diethyl ester
• CAS NO: 3699-83-0
• Molecular Formula: C12H18NO4P
• Molecular Weight: 271.253
• Mol File: 3699-83-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, [2-oxo-2-(phenylamino)ethyl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, [2-oxo-2-(phenylamino)ethyl]-, diethyl ester(3699-83-0)
• EPA Substance Registry System: Phosphonic acid, [2-oxo-2-(phenylamino)ethyl]-, diethyl ester(3699-83-0)

Safety Data

• Hazardous Substances Data: 3699-83-0(Hazardous Substances Data)

Usage

General Description

Phosphonic acid, [2-oxo-2-(phenylamino)ethyl]-, diethyl ester is an organic compound with the chemical formula C12H19NO5P. It is commonly used as a chemical intermediate or building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Phosphonic acid, [2-oxo-2-(phenylamino)ethyl]-, diethyl ester is a diethyl ester of phosphonic acid, and its structure contains a phenylamino group. It is also known by its IUPAC name, diethyl 2-oxo-2-(phenylamino)ethylphosphonate. Phosphonic acid, [2-oxo-2-(phenylamino)ethyl]-, diethyl ester is a colorless to pale yellow liquid and is typically stored and handled under controlled conditions due to its reactivity and potential hazards.

Upstream product

• 34170-81-5 diethyl (2-chloro-2-oxoethyl)phosphonate 
• 62-53-3 aniline 
• 3095-95-2 diethylphosphonoacetic acid 
• 27784-76-5 tert-butyl diethylphosphonoacetate 
• 587-65-5 N-chloroacetyl-aniline 
• 122-52-1 triethyl phosphite 
• 5326-87-4 N-(phenyl)bromoacetamide 
• 683-08-9 Diethyl methylphosphonate 
• 103-71-9 phenyl isocyanate 

Downstream Products

• 113348-16-6 4,4-Diphenyl-buta-2,3-dienoic acid phenylamide 
• 113348-19-9 4-Phenyl-hexa-2,3-dienoic acid phenylamide 

Relevant articles and documents

Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity

Estrogen receptor α (ERα) is an important target for the design of drugs such as tamoxifen (2a) and fulvestrant (5). Three series of ER-ligands based on the benzoxepin scaffold structure were synthesized: series I containing an acrylic acid, series II with an acrylamide, and series III with a saturated carboxylic acid substituent. These compounds were shown to be high affinity ligands for the ER with nanomolar IC50 binding values. Series I acrylic acid ligands were generally ERα selective. In particular, compound 13e featuring a phenylpenta-2,4-dienoic acid substituent was shown to be antiproliferative and downregulated ERα and ERβ expression in MCF-7 breast cancer cells. Interestingly, from series III, the phenoxybutyric acid derivative compound 22 was not antiproliferative and selectively downregulated ERβ. A docking study of the benzoxepin ligands was undertaken. Compound 13e is a promising lead for development as a clinically relevant SERD, while compound 22 will be a useful experimental probe for helping to elucidate the role of ERβ in cancer cells.

Microwave-enhanced synthesis of phosphonoacetamides

An efficient microwave protocol is described for the Michaelis-Arbuzov synthesis of secondary and tertiary N-aryl (and alkyl) (diethylphosphono) acetamides 1, by reaction of chloro- and bromoacetamides with triethyl phosphite in the presence of catalytic

Plant-growth-regulating N-(phosphonoacetyl)amines

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