36998-75-1Relevant academic research and scientific papers
Synthesis, characterization, and antimicrobial activity of benzimidazole-derived chalcones containing 1,3,4-oxadiazole moiety
Meshram, Gangadhar A.,Vala, Vipul A.
, p. 44 - 50 (2015/03/30)
A series of novel benzimidazole-derived chalcones containing the 1,3,4-oxadiazole moiety were synthesized and characterized by IR, 1H, 13C NMR, and mass spectra and elemental analysis. The synthesized compounds were evaluated for their efficiency as antibacterial agents against two Gram-positive and Gram-negative strains of bacteria along with antifungal activity against three fungal species. Antibacterial activity revealed that tested compounds exhibited potent activity whereas some compounds exhibited moderate antifungal activity as compared to the standards.
Microwave assisted transformation of benzimidazolyl chalcones into N 1-substituted pyrazolines and evaluation of their antimicrobial activities
Rajora, Jayanti,Yadav, Janardan,Kumar, Ravindra,Srivastava, Yogendra K.
body text, p. 989 - 993 (2010/11/03)
1-Benzimidazolyl-3-aryl-prop-2-ene-1-ones 2 have been transformed into N1-substituted pyrazoline derivatives by the interaction with phenyl hydrazine, thiosemicarbazide and hydrazine hydrate in the presence of formic acid under solvent microwave induced protocol. The structure of newly synthesized compounds have been confirmed on the basis of their elemental analysis and spectral data. Newly synthesized compounds have been evaluated for their antimicrobial activity in against E. coli, K. pneumonae, P. aeruginosa and B. subtilis using paper disc method. Some of the compounds have shown significant activity against the pathogens.
Synthesis and biological evaluation of some novel-3-(5-substituted benzimidazol-2-yl)-5-arylisoxazolines
Reddy, Vanga Malla,Reddy, Kunduru Ravinder
experimental part, p. 1145 - 1148 (2011/10/08)
The synthesis of a new series of 3-(5-substituted benzimidazol-2-yl)-5-arylisoxazolines (6a-h) was achieved in excellent yields by the condensation of 1-(1H-benzimidazol-2-yl)-3-(substituted phenyl)prop-2-en-1-ones (5a-h) with hydroxylamine at room temperature. These 1-(1H-benzimidazol-2-yl)-3-(substituted phenyl)prop-2-en-1-ones (5a-h) were obtained by the condensation of 2-acetyl benzimidazoles (4a-d) with different aromatic aldehydes, which in turn were obtained by the oxidation of 2-(α-hydroxy)ethyl benzimidazoles (3a-d) prepared by the reaction of o-phenylenediamines (1a-d) with α-hydroxy propionic acid 2. The synthesized compounds were characterized by their IR, 1H NMR and MS analyses. These compounds were screened for their antibacterial and antifungal activity by standard methods and found some of them active.
Synthesis and antimicrobial activity of 2-imino-4-(benzimidazol-2′ -yl)-6-aryl-6H-2,3-dihydro-1,3-thia/oxazines
Vekariya,Khunt,Parikh
, p. 966 - 967 (2007/10/03)
2-Acetylbenzimidazole (1) on condensation with various aldehydes yields the chalcones (2a-1) which on cyclization with thiourea/urea in alc. KOH furnish the corresponding 2-imino-4-(benzimidazol-2′ -yl)-6-aryl-6H-2,3-dihydro-1,3-thiazines/1,3-oxazines (3a-1, 4a-1). The compounds have been evaluated for their antibacterial and antifungal activities.
