36998-76-2Relevant academic research and scientific papers
Ultrasound accelerated synthesis of novel benzimidazole derived chalcones as glucosidases inhibitor and antimicrobial agents
Meshram, Gangadhar A,Vala, Vipul A.,Wagh, Pramod A.,Deshpande, Shruti S.
, p. 613 - 623 (2017/01/18)
A novel series of 3-substituted-1-[1-(toluene-4-sulfonyl)-1H-benzoimidazol-2-yl]-propen-1-one 3a-m have been synthesized by tosylation of benzimidazole chalcones 2a-m using ultrasound in lesser time with higher yields. All the synthesized compounds have been characterized by IR, 1H and 13C NMR, mass and elemental analysis in full accordance with their depicted structure. Biological evaluation of the compounds 3a-m reveals that compound 3f shows moderate inhibition of glucoamylase and compound 3i exhibits compelling inhibition of α-amylase. Compound 3k and 3d display excellent antibacterial activity against all tested strains and admirable antifungal activity against Candida albicans respectively in comparison to the standards. The results of biological study show that introduction of tosyl group in benzimidazole chalcones enhances the inhibition of glycosidases and microorganism in comparison to parent compounds.
Synthesis, characterization, and antimicrobial activity of benzimidazole-derived chalcones containing 1,3,4-oxadiazole moiety
Meshram, Gangadhar A.,Vala, Vipul A.
, p. 44 - 50 (2015/03/30)
A series of novel benzimidazole-derived chalcones containing the 1,3,4-oxadiazole moiety were synthesized and characterized by IR, 1H, 13C NMR, and mass spectra and elemental analysis. The synthesized compounds were evaluated for their efficiency as antibacterial agents against two Gram-positive and Gram-negative strains of bacteria along with antifungal activity against three fungal species. Antibacterial activity revealed that tested compounds exhibited potent activity whereas some compounds exhibited moderate antifungal activity as compared to the standards.
Novel benzimidazole derivatives as expected anticancer agents
Nofal, Zienab M.,Soliman, Elsyed A.,Abd El-Karim, Somaia S.,El-Zahar, Magdy I.,Srour, Aladdin M.,Sethumadhavan, Shalini,Maher, Timothy J.
experimental part, p. 519 - 534 (2012/01/13)
A series of 1-(1H-benzimidazol-2-yl)-3-(substituted)-2-propen-1-one and its 1-methyl analogues 2ch were synthesized and cyclized with different reagents such as ethyl cyanoacetate, thiourea, hydroxylamine hydrochloride, guanidinium sulfate, methylhydrazine, phenylhydrazine and/or hydrogen peroxide in different reactions to produce pyridones 3a,b, pyrimidinethione 4a,b, isoxazole 5a,b, aminopyrimidine 6a,b, pyrazoline 7i-k and epoxy derivative 8, respectively. Acetohydrazide 10 reacted with formic acid, acetic anhydride, carbon disulfide and/or thiosemicarbazide to yield compounds 11-19. Also compound 21a,b was condensed with different monosaccharides to yield the corresponding N-glycoside Schiff's bases derivatives 22a-h, which upon treatment with acetic anhydride afforded 23a-h derivatives. The anticancer activity of some of the newly synthesized compounds was evaluated against HEPG2 (human liver carcinoma cell line) and PC12 (pheochromocytoma of the rat adrenal medulla) cells. Benzimidazole-2-isoxazole 5a derivative exhibited high potency against HEPG2 and PC12 cells. Benzimidazole chalcones 2c,e, benzimidazole mercaptoacetohydrazide 14 and benzimidazole thiosemicarbazide 15a,b derivatives gave high potency against PC12 cells.
Microwave assisted transformation of benzimidazolyl chalcones into N 1-substituted pyrazolines and evaluation of their antimicrobial activities
Rajora, Jayanti,Yadav, Janardan,Kumar, Ravindra,Srivastava, Yogendra K.
body text, p. 989 - 993 (2010/11/03)
1-Benzimidazolyl-3-aryl-prop-2-ene-1-ones 2 have been transformed into N1-substituted pyrazoline derivatives by the interaction with phenyl hydrazine, thiosemicarbazide and hydrazine hydrate in the presence of formic acid under solvent microwave induced protocol. The structure of newly synthesized compounds have been confirmed on the basis of their elemental analysis and spectral data. Newly synthesized compounds have been evaluated for their antimicrobial activity in against E. coli, K. pneumonae, P. aeruginosa and B. subtilis using paper disc method. Some of the compounds have shown significant activity against the pathogens.
