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Usage

Uses

Used in Pharmaceutical Applications:
1-(1H-benzimidazol-2-yl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one is used as a potential candidate in the field of medicinal chemistry for its possible diverse pharmacological activities. 1-(1H-benzimidazol-2-yl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one's unique structure, which includes a benzimidazole ring and a dimethylamino-substituted phenyl group, suggests it may be effective as an enzyme inhibitor, a receptor ligand, or a tool for studying biological processes. Its application in this industry is driven by the need for novel compounds with potential therapeutic properties.
Used in Chemical Research:
In the chemical research industry, 1-(1H-benzimidazol-2-yl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one is used as a chemical probe to study various biological processes. 1-(1H-benzimidazol-2-yl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one's structural elements allow it to interact with biological targets, providing insights into the mechanisms of action and potential applications in drug discovery and development. Its use in this context is motivated by the pursuit of understanding complex biological systems and identifying new therapeutic strategies.

Upstream product

• 100-10-7 4-dimethylamino-benzaldehyde 
• 939-70-8 2-acetylbenzimidazole 
• 16414-04-3 1-benzimidazol-2-ylethanol 

Downstream Products

• 1285695-42-2 2-amino-6-(1H-benzo[d]imidazol-2-yl)-4-(4-(dimethylamino)phenyl)nicotinonitrile 
• 1575824-07-5 6-(1H-benzo[d]imidazol-2-yl)-4-(4-dimethylaminophenyl)-2-(2-(3-nitrophenyl)-4-oxothiazolidin-3-yl)nicotinonitrile 
• 63330-76-7 2-{3-[4-(dimethylamino)phenyl]-2-phenyl-3,4-dihydropyrazol-5-yl}benzimidazole 
• 1250437-03-6 C₁₉H₂₀N₆S 
• 1250436-93-1 C₁₉H₁₉N₅O 

Relevant academic research and scientific papers

Synthesis, antimicrobial, and cytotoxic activities of novel benzimidazole derivatives bearing cyanopyridine and 4-thiazolidinone motifs

A series of 6-(1H-benzo[d]imidazol-2-yl)-2-(2-(3-nitrophenyl)-4- oxothiazolidin-yl)-4-(aryl)nicotinonitriles 5a-l were synthesized and characterized by IR, 1H NMR, 13C NMR, and mass spectrometry techniques. These novel compounds 5a-l were screened for their in vitro antimicrobial activity against different bacterial and fungal strains and in vitro cytotoxicity study (HeLa cell line) using MTT colorimetric assay. The results demonstrated that compounds 5c , 5e, and 5i-k exhibited excellent antibacterial activity, while compounds 5d, 5i, and 5k were found to be the most potent antifungal agents. From the standpoint of SAR studies, it was observed that the presence of electron donating groups remarkably enhanced the antimicrobial activity of newly synthesized compounds. Further, the results of preliminary MTT cytotoxicity studies on HeLa cells suggested that potent antimicrobial activity of 5c-e and 5i-k was accompanied by low cytotoxicity. Springer Science+Business Media 2014.

Microwave assisted transformation of benzimidazolyl chalcones into N 1-substituted pyrazolines and evaluation of their antimicrobial activities

1-Benzimidazolyl-3-aryl-prop-2-ene-1-ones 2 have been transformed into N1-substituted pyrazoline derivatives by the interaction with phenyl hydrazine, thiosemicarbazide and hydrazine hydrate in the presence of formic acid under solvent microwave induced protocol. The structure of newly synthesized compounds have been confirmed on the basis of their elemental analysis and spectral data. Newly synthesized compounds have been evaluated for their antimicrobial activity in against E. coli, K. pneumonae, P. aeruginosa and B. subtilis using paper disc method. Some of the compounds have shown significant activity against the pathogens.

Solid phase synthesis of benzimidazole ketones and benzimidazole chalcones under solvent-free conditions

Oxidation of 1-alkyl/aralkyl-2-(α-hydroxyalkyl/aryl)benzimidazoles 1 with KMnO4 on neutral alumina under solid phase conditions gives the corresponding ketones, 1-alkyl/aralkyl-2-acyl-benzimidazoles 2. Compound 2a (R2 = CH3) on condensation with aromatic aldehydes in the presence of solid NaOH under solvent-free conditions, yields the corresponding chalcones, 1-alkyl/aralkyl-2-benzimidazole aryl vinyl ketone 3.

Synthesis and antimicrobial activity of 2-imino-4-(benzimidazol-2′ -yl)-6-aryl-6H-2,3-dihydro-1,3-thia/oxazines

2-Acetylbenzimidazole (1) on condensation with various aldehydes yields the chalcones (2a-1) which on cyclization with thiourea/urea in alc. KOH furnish the corresponding 2-imino-4-(benzimidazol-2′ -yl)-6-aryl-6H-2,3-dihydro-1,3-thiazines/1,3-oxazines (3a-1, 4a-1). The compounds have been evaluated for their antibacterial and antifungal activities.