3700-14-9Relevant academic research and scientific papers
N-Trifluoromethyl Hydrazines, Indoles and Their Derivatives
Bouayad-Gervais, Samir,Scattolin, Thomas,Schoenebeck, Franziska
, p. 11908 - 11912 (2020)
Reported herein is the first efficient strategy to synthesize a broad range of unsymmetrical N-CF3 hydrazines, which served as platform to unlock numerous currently inaccessible derivatives, such as tri- and tetra-substituted N-CF3 hydrazines, hydrazones, sulfonyl hydrazines, and valuable N-CF3 indoles. These compounds proved to be remarkably robust, being compatible with acids, bases, and a wide range of synthetic manipulations. The feasibility of RN(CF3)-NH2 to function as a directing group in C?H functionalization is also showcased.
