3700-34-3Relevant academic research and scientific papers
Stable and Storable N(CF3)2 Transfer Reagents
Schneider, Leon N.,Tanzer Krauel, Eva-Maria,Deutsch, Carl,Urbahns, Klaus,Bischof, Tobias,Maibom, Kristina A. M.,Landmann, Johannes,Keppner, Fabian,Kerpen, Christoph,Hailmann, Michael,Zapf, Ludwig,Knuplez, Tanja,Bertermann, Rüdiger,Ignat'ev, Nikolai V.,Finze, Maik
supporting information, p. 10973 - 10978 (2021/06/16)
Fluorinated groups are essential for drug design, agrochemicals, and materials science. The bis(trifluoromethyl)amino group is an example of a stable group that has a high potential. While the number of molecules containing perfluoroalkyl, perfluoroalkoxy, and other fluorinated groups is steadily increasing, examples with the N(CF3)2 group are rare. One reason is that transfer reagents are scarce and metal-based storable reagents are unknown. Herein, a set of CuI and AgI bis(trifluoromethyl)amido complexes stabilized by N- and P-donor ligands with unprecedented stability are presented. The complexes are stable solids that can even be manipulated in air for a short time. They are bis(trifluoromethyl)amination reagents as shown by nucleophilic substitution and Sandmeyer reactions. In addition to a series of benzylbis(trifluoromethyl)amines, 2-bis(trifluoromethyl)amino acetate was obtained, which, upon hydrolysis, gives the fluorinated amino acid N,N-bis(trifluoromethyl)glycine.
A convenient synthesis of N,N-bis(trifluoromethyl)anilines
Hirschberg,Ignat'Ev,Wenda,Frohn,Willner
experimental part, p. 176 - 182 (2012/03/27)
A convenient synthesis of N,N-bis(trifluoromethyl)anilines by means of dediazotation reactions of previously unknown aryldiazoniumbis(trifluoromethyl) imides in the presence of CuI salts are described. Properties and applications of N,N-bis(trifluoromethyl)anilines in syntheses of aromatic compounds containing the (CF3)2N group are presented.
