370069-67-3

Basic information

• Product Name: 1,2,3-tris(bromomethyl)benzene
• Synonyms: 1,2,3-tris(bromomethyl)benzene
• CAS NO: 370069-67-3
• Molecular Weight: 356.882
• Mol File: 370069-67-3.mol

Chemical Properties

• CAS DataBase Reference: 1,2,3-tris(bromomethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3-tris(bromomethyl)benzene(370069-67-3)
• EPA Substance Registry System: 1,2,3-tris(bromomethyl)benzene(370069-67-3)

Safety Data

• Hazardous Substances Data: 370069-67-3(Hazardous Substances Data)

Upstream product

• 526-73-8 1,2,3-trimethylbenzene 
• 13651-14-4 (2,3-dimethylphenyl)methanol 

Downstream Products

• 370069-71-9 1,2,3-tris(1,4,7-triazacyclonon-1-ylmethyl)benzene 

Relevant articles and documents

Structural, spectroscopic and electrochemical studies of nickel(II) "sandwich" complexes with ligands featuring tethered 1,4,7-triazacyclononane macrocycles

A structural and electrochemical study of the nickel(II) complexes, [Ni(tacn)2](ClO4)2 (1), [NiLeth](ClO4)2 (2), [NiLox](ClO4)2·H2O (3), [Ni

Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens

The development of novel drugs against Gram-negative bacteria represents an urgent medical need. To overcome their outer cell membrane, we synthesized conjugates of antibiotics and artificial siderophores based on the MECAM core, which are imported by bacterial iron uptake systems. Structures, spin states, and iron binding properties were predicted in silico using density functional theory. The capability of MECAM to function as an effective artificial siderophore in Escherichia coli was proven in microbiological growth recovery and bioanalytical assays. Following a linker optimization focused on transport efficiency, five β-lactam and one daptomycin conjugates were prepared. The most potent conjugate 27 showed growth inhibition of Gram-positive and Gram-negative multidrug-resistant pathogens at nanomolar concentrations. The uptake pathway of MECAMs was deciphered by knockout mutants and highlighted the relevance of FepA, CirA, and Fiu. Resistance against 27 was mediated by a mutation in the gene encoding ExbB, which is involved in siderophore transport.

X-Ray structure determinations of bromo and/or bromomethylsubstituted benzenes: C-H···Br, C-Br···Br, and C-Br···p interactions

The structures of seven benzene derivatives [1,2,3-tri(bromomethyl)benzene, (1); 3,5-di(bromomethyl)bromobenzene, (2); 2,5-di(bromomethyl)bromobenzene, (3); 4-(bromomethyl)-2,5-dibromotoluene, (4); 4-(bromomethyl)bromobenzene, (5); 2,3-di(bromomethyl)bromobenzene, (6) and (bromomethyl)-p-dibromobenzene, (7)] with bromo and bromomethyl (and in one case methyl) substituents are presented and analysed in terms of Br···Br interactions up to 4.0 A , supported by hydrogen bonds H···Br. Some interactions of the type Br···π and π·· · π are encountered and play a subordinate role in the packing. Despite the close chemical similarity of the compounds, some of which are isomers with permuted substituent positions, the packing motifs are highly variable. Compounds 2-5 are based on layer structures with Brn (n=3, 4) and/or mixed Br/C rings. Compounds 1, 6 and 7 display three-dimensional packings of differing complexity, but with interpretable substructures; 1 can be analysed in terms of ribbons of linked Br3 and Br4 rings; 6 displays chains of linked Br3 triangles; 7 consists of ribbons of linked Br4 quadrilaterals.

HIGH STABILITY POLYIONIC LIQUID SALTS

Polyionic liquid salts are provided comprising polycationic or polyanionic molecules. Further provided are solvents comprising one or more polyionic liquid salts, and the use of such polyionic liquid salts as stationary phases in gas chromatography, and as a reagent in electrospray ionization- mass spectrometry (ESI-MS).