370096-67-6

Basic information

• Product Name: 3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide
• Synonyms: 5-(4-chlorophenyl)-1H-pyrazole-3-carbohydrazide;1H-Pyrazole-3-carboxylic acid, 5-(4-chlorophenyl)-, hydrazide
• CAS NO: 370096-67-6
• Molecular Formula: C₁₀H₉ClN₄O
• Molecular Weight: 236.65766
• Mol File: 370096-67-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.427±0.06 g/cm3(Predicted)
• PKA: 10.78±0.10(Predicted)
• CAS DataBase Reference: 3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide(370096-67-6)
• EPA Substance Registry System: 3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide(370096-67-6)

Safety Data

• Hazardous Substances Data: 370096-67-6(Hazardous Substances Data)

Upstream product

• 5814-38-0 ethyl 4-chlorobenzoylpyruvate 
• 99-91-2 para-chloroacetophenone 
• 938182-43-5 5-(4-chloro-phenyl)-2H-pyrazole-3-carboxylic acid ethyl ester 

Downstream Products

• 1353877-17-4 C₂₁H₁₇ClN₄O₄ 
• 1353877-23-2 2-(3-(4-chlorophenyl)-1H-pyrazol-5-yl)-5-(6-methoxy-3-methylbenzofuran-2-yl)-1,3,4-oxadiazole 
• 306285-35-8 N'-[(2-hydroxynaphthalen-1-yl)methylene]-5-(4-chlorophenyl)-1H-pyrazole-3-carbohydrazone 
• 1393587-96-6 (+/-)-3-(4-chlorophenyl)-N-(2-(2-nitrophenyl)-4-oxothiazolidin-3-yl)-1H-pyrazole-5-carboxamide 
• 1393587-97-7 (+/-)-3-(4-chlorophenyl)-N-(2-(3-nitrophenyl)-4-oxothiazolidin-3-yl)-1H-pyrazole-5-carboxamide 
• 1393587-98-8 (+/-)-3-(4-chlorophenyl)-N-(2-(2-chlorophenyl)-4-oxothiazolidin-3-yl)-1H-pyrazole-5-carboxamide 
• 1393587-99-9 (+/-)-3-(4-chlorophenyl)-N-(2-(4-chlorophenyl)-4-oxothiazolidin-3-yl)-1H-pyrazole-5-carboxamide 
• 1284275-59-7 (E)-N'-(4-chlorobenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide 
• 1393587-74-0 (E)-N'-(2-chlorobenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide 
• 1285537-05-4 (E)-N'-(3-nitrobenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide 
• 1393587-66-0 (E)-N'-benzylidene-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide 
• 1393587-71-7 (E)-N'-(4-hydroxybenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide 
• 1284268-03-6 (E)-N'-(4-methoxybenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide 
• 1393587-70-6 (E)-N'-(2-hydroxybenzylidene)-3-(4-chlorophenyl)-1H-pyrazole-5-carbohydrazide 

Relevant articles and documents

Pyrazole-oxadiazole conjugates: Synthesis, antiproliferative activity and inhibition of tubulin polymerization

A number of pyrazole-oxadiazole conjugates were synthesized and evaluated for their ability to function as antiproliferative agents on various human cancer cell lines. These conjugates are comprised of pyrazole and oxadiazole scaffolds closely attached to each other without any spacer as two structural classes. The Type I class has a trimethoxy substituent and the type II class has a 3,4-(methylenedioxy) substituent on their A rings. Among these conjugates, 11a, 11d and 11f manifest potent cytotoxicity with IC50values ranging from 1.5 μM to 11.2 μM and inhibit tubulin polymerization with IC50values of 1.3 μM, 3.9 μM and 2.4 μM respectively. The cell cycle assay showed that treatment with these conjugates results in accumulation of cells in the G2/M phase and disrupts the microtubule network. Elucidation of zebrafish embryos revealed that the conjugates cause developmental defects. Molecular docking simulations determined the binding modes of these potent conjugates at the colchicine site of tubulin.

Synthesis, antitubercular and antimicrobial evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives

As a part of our research to develop novel antitubercular and antimicrobial agents, a series of 3-(4-chlorophenyl)-4-substituted pyrazoles have been synthesised. These compounds were tested for antitubercular activity in vitro against Mycobacterium tuberc