3701-01-7

Usage

Uses

Used in Food and Beverage Industry:
1,3-Benzenedisulfonamide is used as a non-nutritive sweetener for its intense sweetness, making it an ideal sugar substitute in various food and beverage products. It helps in reducing caloric intake and is suitable for people with diabetes or those following a low-sugar diet.
Used in Pharmaceutical Applications:
1,3-Benzenedisulfonamide is used in the treatment of diabetes as a sugar substitute, helping to manage blood sugar levels without adding extra calories. It can be found in medications and supplements designed to assist in diabetes management.
However, it is important to note that there have been concerns regarding the safety and potential carcinogenic properties of 1,3-Benzenedisulfonamide, leading to widespread debate and regulation in its use as a food additive.

InChI:InChI=1/C6H8N2O4S2/c7-13(9,10)5-2-1-3-6(4-5)14(8,11)12/h1-4H,(H2,7,9,10)(H2,8,11,12)

Upstream product

• 585-47-7 benzene-1,3-disulfonyl chloride 
• 831-59-4 1,3-benzenedisulfonic acid disodium salt 

Downstream Products

• 114723-14-7 N,N'-bis-trichlorophosphoranylidene-benzene-1,3-disulfonamide 
• 112069-04-2 N,N'-(m-phenylenedisulfonyl)bis(P,P,P-triphenylphospha-λ⁵-azene) 
• 848408-54-8 N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide 
• 100367-80-4 N,N'-bis-dichlorophosphoryl-benzene-1,3-disulfonamide 
• 108475-61-2 N,N'-(benzene-1,3-disulfonyl)-bis-amidophosphoric acid tetraethyl ester 
• 41596-23-0 N,N,N',N'-tetrachlorobenzene-1,3-disulphonamide 
• 1130324-11-6 C₂₆H₂₁ClN₆O₆S₂ 

Relevant academic research and scientific papers

SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME

ABSTRACT The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.

Mild and regioselective bromination of aromatic compounds with N,N,N′,N′-Tetrabromobenzene-1,3-disulfonylamide and poly(N-bromobenzene-1,3-disulfonylamide)

N,N,N′,N′-Tetrabromobenzene-1,3-disulfonylamide (TBBDA) and poly[N-bromobenzene-1,3-disulfonylamide] (PBBS) can be used for the regioselective bromination of aromatic compounds in excellent yields under mild conditions.

Mild oxidation of 1,3,5-trisubstituted pyrazolines with N-bromo-sulphonamides

1,3,5-Trisubstituted pyrazolines to pyrazoles are carried out efficiently in the presence of new reagents N,N,N′,N′-tetrabromo-benzene-1,3- disulfonylamine [TBBDA] and N,N′-dibromo-N,N′-1,2-ethanediylbis-(p- toluenesulphonamide) [BNBTS] in solvent-free conditions with catalytic amounts of SiO2 under microwave irradiation in high yields.

N,N′,N,N′-tetrabromo-benzene-1,3-disulfonylamide as a novel reagent for oxidative aromatization of 1,3,5-trisubstituted pyrazolines under heterogeneous and solvent-free conditions

1,3,5-Trisubstituted pyrazolines were converted to the corresponding pyrazoles in good yields under heterogeneous and solvent-free conditions by N,N′,N,N′-tetrabromo-benzene-1,3-disulfonylamide [TBBDA] at ambient temperature.