37015-97-7Relevant academic research and scientific papers
Metal free amination of 2-chloroazoles in aqueous medium
Uday Kumar,Reddy, K. Harsha Vardhan,Anil Kumar,Satish,Reddy, V. Prakash,Nageswar
supporting information, p. 637 - 640 (2016/01/26)
A green approach for the synthesis of 2-amino azoles by the reaction of 2-chloro azoles with various types of amines using water as an environment friendly solvent at room temperature has been developed. The significant features of this methodology are short reaction time and easy product separation. This approach provides various biologically active compounds in good to excellent yields without adding any catalyst, ligand, or base.
Synthesis and structure-activity relationship of new piperidinyl and piperazinyl derivatives as antiallergics
Orjales,Bordell,Rubio
, p. 707 - 718 (2007/10/02)
A series of piperazinebenzothiazoles 3-5, piperazinebenzimidazoles 6-12, piperidinobenzothiazoles 14-45, piperidinobenzoxazoles 46-52 and piperidinobenzimidazoles 53-129 has been synthesized and their antiallergic activity evaluated by means of the passive cutaneous anaphylaxis (PCA) assay. Structure-activity relationships are discussed and related to classical antihistaminics. Piperidino derivatives with an aryl group linked to the nitrogen atom by an ethyl chain are the most active compounds, with ID50 1 mg/kg po. Some of these compounds are more potent antiallergics than astemizole and terfenadine.
