3704-26-5

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(3,4,5-Trimethoxybenzoyl)piperidine is used as a building block for the synthesis of various pharmaceuticals and bioactive compounds. Its unique chemical structure allows for the creation of a wide range of molecules with potential therapeutic applications.
Used in Medicinal Chemistry:
1-(3,4,5-Trimethoxybenzoyl)piperidine is used as a key intermediate in the development of new drugs, particularly those targeting the central nervous system. Its structural versatility makes it a valuable component in the design of novel therapeutic agents.
Used in Organic Synthesis:
1-(3,4,5-Trimethoxybenzoyl)piperidine is used as a versatile reagent in organic synthesis, enabling the creation of a diverse array of chemical products with potential applications in various industries.
Used in Neurodegenerative Disease Research:
1-(3,4,5-Trimethoxybenzoyl)piperidine is used as a potential treatment for neurodegenerative diseases due to its pharmacological effects. Its study contributes to the understanding of disease mechanisms and the development of new therapeutic strategies.
Used in Anticonvulsant Drug Development:
1-(3,4,5-Trimethoxybenzoyl)piperidine is used in the development of anticonvulsant drugs, offering a promising avenue for the treatment of epilepsy and other seizure disorders. Its potential to modulate neuronal activity makes it a valuable candidate for further research and development in this area.

InChI:InChI=1/C15H21NO4/c1-18-12-9-11(10-13(19-2)14(12)20-3)15(17)16-7-5-4-6-8-16/h9-10H,4-8H2,1-3H3

Upstream product

• 110-89-4 piperidine 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 24313-88-0 3,4,5-Trimethoxyaniline 
• 201230-82-2 carbon monoxide 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 

Relevant academic research and scientific papers

Direct Synthesis of Enamides via Electrophilic Activation of Amides

A novel, one-step N-dehydrogenation of amides to enamides is reported. This reaction employs the unlikely combination of LiHMDS and triflic anhydride, which serves as both the electrophilic activator and the oxidant, and is characterized by its simple setup and broad substrate scope. The synthetic utility of the formed enamides was readily demonstrated in a range of downstream transformations.

In situ protection and deprotection of amines for iron catalyzed oxidative amidation of aldehydes

An environmentally friendly synthetic route by the application of CO2 to synthesize amides via in situ protection and deprotection of amines for iron catalyzed oxidative amidation of aldehydes was developed. Various secondary and tertiary amides have been synthesized in moderate to good yields under mild and neutral reaction conditions. The use of amine hydrochloride salts and hence base for neutralization step is totally avoided in this protocol.

N2 extrusion and co insertion: A novel palladium-catalyzed carbonylative transformation of aryltriazenes

A novel procedure for the replacement of N2 with CO of aryltriazenes has been developed. Aryltriazenes were converted to the corresponding arylamides catalyzed by 1 mol % of PdCl2/P(o-Tol)3 under CO pressure. In this process, aryldiazonium salts were generated in the presence of 40 mol % of MeSO3H. Nitrogen was released from the substrates and CO formally inserted. Aryl bromides, iodides, alkynes, and free hydroxyl groups can be tolerated in this transformation.

Synthesis and CNS-depressant profile of 3,4,5-trimethoxybenzoyl analogues

A series of 3,4,5-trimethoxybenzoyl analogues with varying electronic and stereochemical characteristics has been synthesized. Many of these compounds (4, 5, 9, 12, 15) showed appreciable potentiation of pentobarbitone-induced hypnosis. Several analogues (1, 5, 6, 11, 12, 15) exhibited marked reduction of spontaneous motor activity (SMA).