370561-60-7

Basic information

• Product Name: 1H-Pyrazole-4-carboxaldehyde, 3-(4-chlorophenyl)-1-phenyl-, oxime
• CAS NO: 370561-60-7
• Molecular Formula: C16H12ClN3O
• Molecular Weight: 297.744
• Mol File: 370561-60-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-4-carboxaldehyde, 3-(4-chlorophenyl)-1-phenyl-, oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-carboxaldehyde, 3-(4-chlorophenyl)-1-phenyl-, oxime(370561-60-7)
• EPA Substance Registry System: 1H-Pyrazole-4-carboxaldehyde, 3-(4-chlorophenyl)-1-phenyl-, oxime(370561-60-7)

Safety Data

• Hazardous Substances Data: 370561-60-7(Hazardous Substances Data)

Upstream product

• 36663-00-0 1-phenyl-3-(4-chlorophenyl)-4-pyrazolecarboxaldehyde 
• 68-12-2 N,N-dimethyl-formamide 
• 57845-08-6 p-chloroacetophenone phenylhydrazone 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 1423043-83-7 5-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-2H-tetrazole 
• 1246454-58-9 C₂₂H₂₀ClN₃O 
• 372098-17-4 3-(p-chlorophenyl)-1-phenyl-1H-pyrazole-4-carbonitrile 

Relevant articles and documents

Microwave-assisted synthesis and biological evaluation of pyrazole-4-carbonitriles as antimicrobial agents

An efficient microwave-assisted method of synthesis of pyrazole-4-carbonitriles has been developed. Condensation of pyrazole-4-carbaldehydes with hydroxylamine hydrochloride followed by reaction of the resulting oximes with the Vilsmeier-Haack reagent pre-formed from phthaloyl dichloride and dimethylformamide under microwave irradiation afforded the corresponding pyrazole-4-carbonitriles in 73percent to 91percent yield. The operational simplicity, avoidance of toxic reagents such as POCl3, shorter reaction time, higher yield compared to the classical version, easy work up, and the use of the by-product in the regeneration of phthaloyl dichloride are the advantages of this methodology. All the target compounds were tested for antimicrobial activity against Gram-positive bacteria Bacillus cereus and Staphylococcus aureus; Gram-negative bacteria Escherichia coli and Yersinia enterocolitica, and the fungal species Candida albicans.

Design, synthesis, in Silico toxicity prediction, molecular docking, and evaluation of novel pyrazole derivatives as potential antiproliferative agents

A new series of pyrazole derivatives were designed by docking into vascular endothelial growth factor receptor-2 (VEGFR-2) kinase active site. The designed compounds were synthesized and evaluated for in vitro antiproliferative activity against HT-29 colo

Synthesis and antinociceptive activity of pyrazolyl isoxazolines and pyrazolyl isoxazoles

Pyrazolyl isoxazolines and isoxazoles were synthesised in moderate to good yields using 1,3-dipolar cycloaddition of pyrazole derived nitrile oxide with various dipolarophiles such as N-substituted maleimide, diethylacetylene dicarboxylate and phenylacety