370580-83-9Relevant academic research and scientific papers
2-acyl indole derivatives and their use as antitumor agents
-
, (2008/06/13)
The invention relates to novel indole and heteroindole derivatives of the formula I to their tautomers, their stereoisomers, their mixtures and their salts, to their preparation and to the use of indole derivatives of the formula I as antitumor agents.
Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents
Mahboobi,Pongratz,Hufsky,Hockemeyer,Frieser,Lyssenko,Paper,Bürgermeister,B?hmer,Fiebig,Burger,Baasner,Beckers
, p. 4535 - 4553 (2007/10/03)
A new class of simple synthetic antimitotic compounds based on 2-aroylindoles was discovered. (5-Methoxy-1H-2-indolyl)-phenylmethanone (1) as well as analogous 3-fluorophenyl- (36) and 3-methoxyphenyl (3) derivatives displayed high cytotoxicity of IC
