37065-52-4

Upstream product

• 111-83-1 1-bromo-octane 
• 121-71-1 3-Hydroxyacetophenone 

Downstream Products

• 1154701-63-9 C₁₆H₂₆O₂ 
• 111651-86-6 (Z)-3-Hydroxy-1-(3-octyloxy-phenyl)-propenone 
• 111651-84-4 (S)-2-Amino-4-{(R)-1-(carboxymethyl-carbamoyl)-2-[(E)-3-(3-octyloxy-phenyl)-3-oxo-propenylsulfanyl]-ethylcarbamoyl}-butyric acid 

Relevant academic research and scientific papers

PRACTICAL, STABLE STANDARDS FOR THE REVERSED PHASE HPLC ANALYSIS OF PEPTIDIC LEUKOTRIENES

The stable glutathione derivatives 1, R= n-C6H13 and R= n-C8H17, are useful as reference compounds for the identification and quantitation of leukotrienes C4, D4 and E4 by reversed phase HPLC analysis.

Design, synthesis, biological evaluation and inhibition mechanism of 3-/4-alkoxy phenylethylidenethiosemicarbazides as new, potent and safe tyrosinase inhibitors

Tyrosinase plays important roles in many different disease related processes, and the development of its inhibitors is particularly important in biotechnology. In this study, thirty-nine 3-/4-alkoxyphenylethyli-denethiosemicarbazides were synthesized as novel tyrosinase inhibitors based on structure-based molecular design. Our experimental results demonstrated that thirty-one of them possess remarkable tyrosinase inhibitory activities with IC50 value below 1μM, and 5a, 6e, 6g and 6t did not display any toxicity to 293T cell line at the concentration of 1000μmol/L. According to the inhibitory activities, several compounds were selected for detail investigation on the structure–activity relationships (SARs), mechanisms of enzyme inhibition, inhibitory kinetics and cytotoxicity. In particular, the interaction between the selected inhibitors and the active center of tyrosinase was considered and discussed in detail based on their structural characteristics. Taken together, the results presented here demonstrated that the newly designed compounds are promising candidates for the treatment of tyrosinase-related disorders and further development of them may have significant contribution in biomedical science.

Non-symmetric dimers comprising chalcone and cholesterol entities: An investigation on structure-property correlations

Four series of new dimers formed by interlinking chalcone and cholesterol mesogenic entities through spacers of varying length and parity have been synthesized and characterized by polarizing optical microscopy, differential scanning calorimetry, X-ray diffraction and electrical switching studies. The structure of the chalcone core has been systematically modified to investigate the effect of the molecular structure on the thermal behaviour of the dimers. The study demonstrates the dramatic dependence of thermal behaviour of these dimers on the nature of the chalcone as well as the length and parity of the spacer. the Partner Organisations 2014.

Reactivity in micelles - Are we really able to design micellar catalysts?

Coordination of lipophilic alkyl pyridin-2-yl ketoximes 1 to Ni 2+ ions, reduction of lipophilic 3-alkoxyacetophenones 2 with sodium borohydride, and alkaline hydrolysis of 4-nitrophenyl diphenyl phosphate (PNPDPP) were employed as probes in the investigation which factors may influence the reactivity of organic compounds in micellar systems. In all these reactions, a lipophilic substrate solubilized in micellar core was attacked by a hydrophilic reagent from the bulk aqueous phase. To evaluate the contribution of electrostatic interactions between the micellar surface charge and the reagent to the observed reactivity, we combined reactions involving the reagents with opposite polarity (Ni2+ cations and borohydride or hydroxide anions) with positively charged micelles of hexadecyltrimethyl-ammonium chloride (CTAC) or bromide (CTAB) and negatively charged micelles of sodium dodecyl sulfate (SDS). Non-ionic micelles (Triton X-100 or Brij 35) served as a reference. The results of the kinetic studies give evidence that each of the investigated systems has unique properties going in particular aspects beyond the scope of the generally accepted concepts of reactivity in micelles.

Mesomorphic properties of 1-(4'-dodecylbiphenyl-4-yl)-3-(2 or 3-alkoxyphenyl)propane-1,3-diones: the influence of alkoxysubstituent position

Two homologous series of β-diketones, viz. 1-(4'-dodecylbiphenyl-4-yl)-3-(2-alkoxyphenyl)propane-1,3-diones and 1-(4'-dodecylbiphenyl-4-yl)-3-(3-alkoxyphenyl)propane-1,3-diones have been synthesised.The mesomorphic behaviour of all the compounds has been investigated using optical polarising microscopy and differential scanning colorimetry.The enthalpies associated with the transitions of all the liquid crystalline materials have also been determined.The mesophases exhibited by these compounds are explained on the basis of the structural features associated with such compounds.