370839-73-9Relevant academic research and scientific papers
Deprotection of 2-pyridyl sulfonyl group from pyridine-2-sulfonamides by magnesium in methanol
Chwang Siek Pak,Dong Sung Lim
, p. 2209 - 2214 (2001)
Convenient deprotection of various pyridine-2-sulfonamides prepared by sulfonylation of primary and secondary amines with pyridine-2-sulfonylchloride was achieved by magnesium in methanol at 0°C to the corresponding amines in good yield.
Novel nitrogen to carbon rearrangement forming nicotinic acid sulfonamides
Rushingwa, Evelyne,Touray, Hadijatou K.,Bowen, Richard D.,Gallagher, Richard T.,Martin, William H.C.
supporting information, p. 4726 - 4728 (2013/08/23)
The synthesis of nicotinic acid derivatives via the base-mediated nitrogen to carbon rearrangement of N-substituted pyridine 2-sulfonamides is reported. This noteworthy isomerisation of the pyridine sulfonamide protecting group has implications for the use of this protecting group in synthesis.
