370847-39-5

Basic information

• Product Name: 2-((4-methylbenzyl)thio)-3,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one
• Synonyms: 2-((4-methylbenzyl)thio)-3,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one
• CAS NO: 370847-39-5
• Molecular Formula: C₁₅H₁₆N₂OS
• Molecular Weight: 272.36534
• Mol File: 370847-39-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-((4-methylbenzyl)thio)-3,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((4-methylbenzyl)thio)-3,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one(370847-39-5)
• EPA Substance Registry System: 2-((4-methylbenzyl)thio)-3,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one(370847-39-5)

Safety Data

• Hazardous Substances Data: 370847-39-5(Hazardous Substances Data)

Upstream product

• 10472-24-9 methyl 2-oxocyclopentane-1-carboxylate 
• 35563-27-0 2-sulfanylidene-1,2,3,4,6,7-hexahydro-5H-cyclopenta[d]pyrimidin-4-one 
• 104-81-4 4-Methylbenzyl bromide 

Relevant articles and documents

Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds

Matrix metalloproteinase-13 (MMP-13) has been implicated as the protease responsible for collagen degradation in cartilage during osteoarthritis (OA). Compounds that inhibit the metalloproteinase at the Zn binding site typically lack specificity among MMP family members. Analogs of the low-micromolar lead MMP-13 inhibitor 4, discovered through high-throughput screening, were synthesized to investigate structure-activity relationships in this inhibitor series. Systematic modifications of 4 led to the discovery of MMP-13 inhibitors 20 and 24 which are more selective than 4 against other MMPs. Compound 20 is also approximately fivefold more potent as an MMP-13 inhibitor than the original HTS-derived lead compound 4.