370864-72-5

Usage

Uses

Used in Pharmaceutical Industry:
3-(Piperidin-4-yl)benzonitrile is used as an intermediate in the synthesis of various pharmaceuticals for its sedative and analgesic properties. It is particularly valuable in the development of medications targeting central nervous system disorders, given its potential therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(Piperidin-4-yl)benzonitrile serves as a key intermediate in the production of agrochemicals, contributing to the development of effective pest control agents and other agricultural products.
Used in Organic Synthesis:
3-(Piperidin-4-yl)benzonitrile is utilized as a building block in organic synthesis, enabling the creation of a diverse range of heterocyclic compounds with potential biological activities. Its structural versatility makes it a valuable component in the synthesis of new compounds with therapeutic or other beneficial properties.
It is crucial to handle 3-(Piperidin-4-yl)benzonitrile with care due to its potential health and environmental hazards, ensuring proper management and safety measures are in place throughout its use in various applications.

Upstream product

• 370864-73-6 tert-butyl 4-(3-cyanophenyl)piperidine-1-carboxylate 
• 6952-59-6 3-cyanobromobenzene 
• 14221-01-3 tetrakis(triphenylphosphine) palladium⁽⁰⁾ 
• 497-19-8 sodium carbonate 
• 150255-96-2 (3‐cyanophenyl)boronic acid 
• 138647-49-1 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 370864-42-9 4-(3-cyanophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 

Downstream Products

• 851961-36-9 3-[1-(5-phenylethynyl-pyridine-3-carbonyl)-piperidin-4-yl]-benzonitrile 
• 1004618-19-2 3-(1-((1-methyl-1H-benzo[d]imidazol-2-yl)methyl)piperidin-4-yl)-benzonitrile 

Relevant academic research and scientific papers

BENZOXAZINYL-AMIDOCYCLOPENTYL-HETEROCYCLIC MODULATORS OF CHEMOKINE RECEPTORS

Cyclopentyl compounds linked to a benzoxazinyl group through an amido moiety utilizing the ring nitrogen of the benzoxazine, and further substituted with a heterocyclic moiety, such compounds represented by formula I: which are used to modulate the CCR-2 chemokine receptor to prevent or treat inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis; and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions.

Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: Novel, potent, selective, and orally bioavailable inhibitors of βII tryptase

Tryptase is a serine protease found almost exclusively in mast cells. It has trypsin-like specificity, favoring cleavage of substrates with an arginine (or lysine) at the P1 position, and has optimal catalytic activity at neutral pH. Current evidence suggests tryptase β is the most important form released during mast cell activation in allergic diseases. It is shown to have numerous pro-inflammatory cellular activities in vitro, and in animal models tryptase provokes broncho-constriction and induces a cellular inflammatory infiltrate characteristic of human asthma. Screening of in-house inhibitors of factor Xa (a closely related serine protease) identified β-amidoester benzamidines as potent inhibitors of recombinant human βII tryptase. X-ray structure driven template modification and exchange of the benzamidine to optimize potency and pharmacokinetic properties gave selective, potent and orally bioavailable 4-(3-aminomethyl phenyl)piperidinyl-1-amides.

1-aroyl-piperidinyl benzamidines

This invention relates to compounds of formula which inhibit Factor Xa or tryptase, to pharmaceutical compositions containing the compounds, and to the use of the compounds for the treatment of patients suffering from conditions which can be ameliorated by the administration of an inhibitor of Factor Xa or tryptase.