370867-67-7Relevant articles and documents
Synthetic studies of the cyclic depsipeptides bearing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit. Total synthesis of the proposed structure of micropeptin T-20
Yokokawa, Fumiaki,Inaizumi, Akiko,Shioiri, Takayuki
, p. 1459 - 1480 (2005)
The first total synthesis of a cyclic depsipeptide possessing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit was successfully achieved in a convergent manner by the oxidative construction of the Ahp unit at the later stage of the synthesis. This synthetic work provides data indicating that the structure of the target Ahp-depsipeptide, micropeptin T-20, should be re-examined.
Synthetic studies of micropeptin T-20, a novel 3-amino-6-hydroxy-2-piperidone (Ahp)-containing cyclic depsipeptide
Yokokawa, Fumiaki,Inaizumi, Akiko,Shioiri, Takayuki
, p. 5903 - 5908 (2007/10/03)
The synthetic studies of micropeptin T-20 including the late installation of the Ahp (3-amino-6-hydroxy-2-piperidone) residue through oxidation and cyclization of a homoserine to the requisite hemiaminal are described.