370877-57-9Relevant academic research and scientific papers
BIARYL KINASE INHIBITORS
-
Page/Page column 279; 280, (2017/05/07)
The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAKl (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.
Cycloaddition of N-substituted imines of trifluoropyruvate with diazomethane: Efficient synthesis of 2-(trifluoromethyl)aziridine-2-carboxylates
Rassukana, Yuliya V.,Bezgubenko, Ludmyla V.,Onys'Ko, Petro P.,Synytsya, Anatoly D.
, p. 14 - 18 (2013/04/10)
A convenient synthesis for 2-trifluorometylaziridine-2-carboxylates and respective acids, based on reaction of N-substituted trifluoropyruvate imines 1 with diazomethane, was developed.
Fluorine-containing α-alkynyl amino esters and access to a new family of 3,4-dehydroproline analogues
Semeril,Le Notre,Bruneau,Dixneuf,Kolomiets,Osipov
, p. 16 - 18 (2007/10/03)
New α-alkynyl, α-CF3 amino esters have been prepared from electrophilic imines and used to produce 3-alkenyl-3,4-dehydroproline derivatives, via enyne metathesis with the precatalyst [Ru=C=C=CPh2(Cl)(PCy3)(arene)]O3/
